Results 61 to 70 of about 3,848,803 (345)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Sprache als Erinnerungsort der Kultur: Die Bedeutung von Wortfeldern für das Sprachverständnis

Interkulturelles Forum der deutsch-chinesischen Kommunikation
Dieser Artikel behandelt das Thema Kultur und Wortfelder. An Stelle der realen Welt stellt jede Sprache eine halb fiktive Version von Dingen dar. Sprache schafft ihre eigene Sicht auf die Welt. Dies führt zu unterschiedlichen Wortfeldern für jede Sprache.
Klatt Gunnar, Qi Dongdong
doaj   +1 more source

Subject-verb agreement in German in bilingual children with and without SLI

Zeitschrift für Sprachwissenschaft, 2017
We investigated the acquisition of subject-verb agreement (SVA) in German based on spontaneous speech data from both typically developing (TD) and language-impaired (SLI) children learning German as a second language (L2), and from language-impaired ...
Rothweiler Monika, Schönenberger Manuela, Sterner Franziska   +2 more
doaj   +1 more source

Interaktion im wissenschaftlichen Fachtext aus kontrastiver Sicht. Untersucht anhand von deutschen und lettischen linguistischen Aufsätzen [PDF]

Linguistische Treffen in Wrocław
Linguistic specialised communication can take place in various ways, and the ‘pure’ technical language formulations are combined with those used in everyday scientific language to enable interaction between the author and the addressee, as well as to ...
Agnese Dubova, Diāna Laiveniece, Dzintra Lele-Rozentāle   +2 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Weisheit der Völker oder Weisheit auf der Gasse? Nationale Stereotype in polnischen und deutschen Sprichwörtern aus dem 18. und 19. Jahrhundert [PDF]

Linguistische Treffen in Wrocław
The article presents stereotypical linguistic images of Poland and Germany recorded in codified proverbs containing adjectives Polish and German, names of countries, their inhabitants and languages.
Małgorzata Guławska-Gawkowska
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Heavy Quark Impact Factor at Next-to-leading Level [PDF]

, 2000
We further analyze the definition and the calculation of the heavy quark impact factor at next-to-leading (NL) log(s) level, and we provide its analytical expression in a previously proposed k-factorization scheme.
Ciafaloni, Marcello, Rodrigo, German
core   +3 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

TÜRK VE ALMAN İLKÖĞRETİM 5. SINIF ÖĞRENCİLERİNİN DİLBİLGİSİDERS KİTAPLARINDAKİ SIFATLARIN NİCELİK BAKIMINDAN KARŞILAŞTIRILMASI

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2006
Öğrenmeye başladığımız ilk günden ulaştığımız yaşa kadar, sürekli bir şekilde yeni şeylerin isimlerini sözcük dağarcığımıza katıyoruz. 8 sözcük türünden biri olan sıfatlar, nesneleri algılamada, tanımlamada ve ayırt etmede önemli bir görev üstlenirler ...
Rıdvan Tunçel
doaj