Results 71 to 80 of about 177,757 (312)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

INSTITUŢIA BISERICII CA INSTRUMENT DE COORDONARE A VIEŢII SPIRITUALE A COLONIŞTILOR GERMANI DIN BASARABIA (1814-1875)

open access: yesStudia Universitatis Moldaviae: Stiinte Umanistice, 2017
În materialul prezentat, autorul, pornind de la general spre particular şi bazându-se pe sursele documentare şi analiza istoriografiei, încearcă o analiză a ceea ce a însemnat instituţia bisericii protestante în viaţa comunităţilor germane.
Ion GUMENÂI
doaj  

Le kiswahili : une politique linguistique d’exception au Tanganyika

open access: yesLes Cahiers d’Afrique de l’Est, 2012
This article presents the language policy in Tanganyika under German and British colonizations through textbooks. In this territory, the language of instruction was Swahili, an African language used and propagated by Muslim traders, and then European ...
Aude Chanson
doaj   +1 more source

Immigration and the origins of regional inequality: Government-sponsored European migration to Southern Brazil before World War I [PDF]

open access: yes
This paper studies the long-term consequences of the government-sponsored programs of European immigration to Southern Brazil before the Great War. We find that the municipalities closer to the original sites of nineteenth century government sponsored ...
de Carvalho Filho, Irineu   +1 more
core   +1 more source

Heterospecific Hymenoptera found inside the nests of Bombus impatiens (Hymenoptera: Apidae). [PDF]

open access: yes, 2018
The nests of social Hymenoptera are particularly attractive to species engaging in resource robbing due to their concentration of resources. Here, the identity of heterospecific intruders in Bombus impatiens nests are described, with a particular focus ...
Graham, Kelsey K
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Historische Sprachkontaktforschung zur deutschen Sprache im Südpazifik - Ansatz zu einer Quellen- und Dokumentenkunde der Deutschen Koloniallinguistik [PDF]

open access: yes, 2015
Investigations of the relationship between language and German colonialism are mainly based on historical sources. The article aims to develop a systematic foundation of source studies as a methodological background for these investigations.
Engelberg, Stefan
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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