Results 41 to 50 of about 29,593 (220)

AGMB 2023: Zukunft – jetzt erst recht

GMS Medizin – Bibliothek – Information, 2023
The 2023 annual conference of the German Medical Libraries Association (AGMB) in Bonn was held under the motto “AGMB 2023: Future – now more than ever”. There were numerous lectures and short presentations, posters and workshops.
Reimann, Iris
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

SWOT-Analyse zu den Dienstleistungen für Systematische Reviews medizinischer Bibliotheken in D-A-CH-Ländern

GMS Medizin – Bibliothek – Information, 2020
In Spring 2020, an online survey was realized among all medical librarians in Germany, Austria and Switzerland on behalf of the Evidence Based Medicine Working Group (AG-EBM) of the German Medical Library Association. The main focus of this survey was to
Cascant Ortolano, Lorena, Schweizer, Stefanus   +1 more
doaj   +1 more source

Aus der AGMB

GMS Medizin – Bibliothek – Information, 2023
The conference in Bonn is summarized. The results of the general meeting and the board election are presented.
Jirausch, Claudia
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

„AGMB 2025. Synergien schaffen: Informationswissenschaften und Medizin im Dialog“. Jahrestagung der Arbeitsgemeinschaft für Medizinisches Bibliothekswesen (AGMB) e.V. vom 22. bis 24. September in Linz

GMS Medizin – Bibliothek – Information
“AGMB 2025. Create synergies: Information sciences and medicine in dialogue” was the theme of the annual conference of the German Medical Library Association (AGMB), held in Linz from September 22 to 24, 2025.
Claudia Jirausch, Christian Vogel, Julia Letow, Sandra Stops   +3 more
doaj   +1 more source

Medizinbibliotheken: offen und innovativ aus Tradition

GMS Medizin – Bibliothek – Information, 2018
The focus of the current issue 3/2018 of GMS Medi Bibliothek – Information is on the annual conference 2018 of the German Medical Libraries Association in Oldenburg.
Bauer, Bruno
doaj   +1 more source