Results 71 to 80 of about 41,715 (245)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
GMS Medizin – Bibliothek – Information, 2010 The focus of the current issue 3/2010 of GMS Medizin – Bibliothek – Information is the annual conference 2010 of the German Medical Libraries Association in Mainz. The motto of the conference was “all – simply – immediately: service in medical libraries”.
Bauer, Bruno
doaj
Mitteilungen aus der Arbeitsgemeinschaft Evidenzbasierte Medizin der AGMB
GMS Medizin – Bibliothek – InformationThe working group Evidence-Based Medicine (AG-EBM) of the German Medical Library Association (AGMB) celebrates its fifth anniversary in 2024. It continues its work in the years 2023 and 2024 in the form of virtual meetings.
von Gernler, Marc +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
GMS Medizin – Bibliothek – Information, 2011 The focus of the current issue 3/2011 of GMS Medizin – Bibliothek – Information is the annual conference 2011 of the German Medical Libraries Association in Cologne.
Bauer, Bruno
doaj
GMS Medizin – Bibliothek – Information, 2012 [english] The focus of the current issue 3/2012 of GMS Medizin – Bibliothek – Information is the annual conference 2012 of the German Medical Libraries Association in Aachen. The motto of the conference was “Medical Libraries 20XX.
Bauer, Bruno
doaj +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
AGMB 2024: Den Wandel steuern – Medizininformation effizient.digital.innovativ
GMS Medizin – Bibliothek – InformationThis issue of GMS Medizin – Bibliothek – Information takes up the topics of the 2024 annual conference of the German Medical Libraries Association (AGMB) in Mainz.
Reimann, Iris
doaj +1 more source