Results 141 to 150 of about 27,772,219 (267)

Immunoadsorption in dilated cardiomyopathy: the IASO-DCM trial. [PDF]

Eur Heart J
Felix SB, Böhm M, Braun-Dullaeus RC, Caforio ALP, Erdmann E, Grabmaier U, Groß S, Klingel K, Knebel F, Lehnert K, Mahabadi AA, Mitrovic V, Nauck M, Nickening G, Noutsias M, Sandek A, Schultheiss HP, Schulze C, Schunkert H, Seferovic PM, Stangl K, Staudt A, Tschöpe C, Wachter R, Wegner D, Werdan K, Waagstein F, Hjalmarson Å, Dörr M.   +28 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A precision approach to translational research in acute lung injury. [PDF]

Am J Respir Crit Care Med
Albaiceta GM, Dos Santos CC, Zemans RL, Kuebler WM.   +3 more
europepmc   +1 more source

Student micro-publications in archival tradition-building. Project funding by the German Research Foundation

Authors: Dennis Hormuth and Gunnar B. Zimmermann At universities, students make up the largest group of people – at the University of Hamburg, for example, with over 42,000 enrolled students in the 2022/2023 academic year, compared to around 15,000 employees, including over 9,000 employees at the University Medical Center.
openaire   +2 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

DNA origami-based virus-like particles: a new class of HIV vaccine candidates with superior immunogenic properties. [PDF]

Signal Transduct Target Ther
Muecksch F, Hamdan J, Fackler OT.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Comprehensive assessment of novel cardiovascular biomarkers in AF. [PDF]

Europace
Ohlrogge AH, Engler D, Schlieker P, Seum F, Rosebrock K, Nebel N, Csengeri D, Fabritz L, Ziegler A, Blankenberg S, Kirchhof P, Zeller T, Schnabel RB.   +12 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Author Correction: Large-scale self-supervised video foundation model for intelligent surgery. [PDF]

NPJ Digit Med
Yang S, Zhou F, Mayer L, Huang F, Chen Y, Wang Y, He S, Nie Y, Wang X, Sümer Ö, Jin Y, Sun H, Xu S, Liu AQ, Li Z, Qin J, Teoh JY, Maier-Hein L, Chen H.   +18 more
europepmc   +1 more source