Results 141 to 150 of about 215,077 (307)

Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1

, 2015
Jin, Saihong et al.Myogenic regulatory factors such as MyoD and Myf5 lie at the core of vertebrate muscle differentiation. However, E-boxes, the cognate binding sites for these transcription factors, are not restricted to the promoters/enhancers of ...
García-Domínguez, Mario, Kieslinger, Matthias, Jin, Saihong   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Allopatric speciation illustrated: The hypogean genus Geotrechus Jeannel, 1919 (Coleoptera: Carabidae: Trechini), with description of four new species from the Eastern Pyrenees (Spain)

, 2015
We present a study of the eastern group of species of the genus Geotrechus (Coleoptera, Carabidae, Trechini), combining molecular and morphological approaches. Four new species are described from caves of the Pyrenees of Catalonia, Spain.
Faille, Arnaud, Bourdeau, Charles, Bourdeau,Charles, Faille,Arnaud, Fresneda,Javier, Belles,Xavier, Fresneda, Javier, Bellés, Xavier   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

German Research Foundation establishes new Collaborative Research Centers [PDF]

MRS Bulletin, 2014
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of chlorine ion chemistry on ozone loss in the middle atmosphere during very large solar proton events [PDF]

Solar coronal mass ejections can accelerate charged particles, mostly protons, to high energies, causing solar proton events (SPEs). Such energetic particles can precipitate upon the Earth's atmosphere, mostly in polar regions because of geomagnetic ...
Laeng, Alexandra, Maik Wissing, Jan, Reddmann, Thomas, von Clarmann, Thomas, Yakovchuk, Olesya, Braesicke, Peter, Stiller, Gabriele, Usoskin, Ilya, Borthakur, Monali, Sinnhuber, Miriam, Funke, Bernd   +10 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Phylogenomics including new sequence data of phytoplankton-infecting chytrids reveals multiple independent lifestyle transitions across the phylum

11 pages, 6 figures, supplementary data https://doi.org/10.1016/j.ympev.2024.108103Parasitism is the most common lifestyle on Earth and has emerged many times independently across the eukaryotic tree of life.
Wolinska, Justyna, Grossart, Hans-Peter, Monaghan, Michael T., Garcés, Esther, Strassert, Jürgen F.H., Van Den Wyngaert, Silke, Agha, Ramsy, Thomé, Pauline C., Reñé, Albert, Ilicic, Doris   +9 more
core   +1 more source