Results 241 to 250 of about 1,018,571 (313)

Cost-Effectiveness Analysis of the Milan System for Reporting Salivary Gland Cytopathology in Fine-Needle Aspiration Cytology of Salivary Gland Lesions. [PDF]

Cancer Med
Jansen L, Nachtsheim L, Kourou S, Wolber P, Sharaf K, Hansen K, Shabli S, van de Loo J, Quaas A, Arolt C, Engels M, Hieggelke L, Morris LGT, Klussmann JP, Mayer M.   +14 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Use of optical coherence tomography in the care of people with multiple sclerosis in Switzerland: A national survey among neurologists. [PDF]

Mult Scler J Exp Transl Clin
Kana V, Herwerth M, Gugleta K, Bernard-Valnet R, Mueller S, Mallucci G, Fierz FC, Granziera C, Kuhle J, Roth P, Papadopoulou A.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

On-surface synthesis platform for highly branched oligomers based on sequential C-C coupling and C-H activation of carbenes. [PDF]

Nat Commun
Cao Y, Mieres-Perez J, Rowen JF, Raut AH, Schweer P, Bao A, Sander W, Sanchez-Garcia E, Morgenstern K.   +8 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Improving Retrieval Augmented Generation for Health Care by Fine-Tuning Clinical Embedding Models: Development and Evaluation Study.

J Med Internet Res
Arzideh K, Schäfer H, Idrissi-Yaghir A, Schmidt CS, Eryilmaz B, Bahn M, Turki AT, Pollok OB, Hartmann EM, Winnekens P, Borys K, Haubold J, Nensa F, Hosch R.   +13 more
europepmc   +1 more source

Performance of DeepSeek-R1, ChatGPT (GPT-o3-mini), and Gemini 2.0 Flash on German Medical Multiple-Choice Questions: Comparative Evaluation. [PDF]

JMIR Form Res
Meyer A, Karay Y, Steinbicker AU, Streichert T, Overbeek R.   +4 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source