Results 61 to 70 of about 327,377 (313)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Zur Leistung der Abstrakta in der studentischen Wissenschaftssprache: ein quantitativer L1-L2-Vergleich

open access: yesLinguistik Online, 2020
This article examines the role of abstract nouns which are used to carry propositional content. These are referred to here as “satzbezogene nominale Verweise” (SNV) and they are operationalised using a combination of semantic, functional and structural ...
Tomáš Mach
doaj  

Maori thinking with a dead white male: Philosophizing in the realm of Novalis [PDF]

open access: yes, 2014
In this paper I shall discuss my experiences of referring to Novalis in the context of Maori postcolonialism and metaphysical philosophy. As with other methods of research, from a Maori perspective one always alights on and then carries the effects of ...
Mika, Carl Te Hira
core   +1 more source

Orthography and Identity in Cameroon [PDF]

open access: yes, 2001
The tone languages of sub-Saharan Africa raise challenging questions for the design of new writing systems. Marking too much or too little tone can have grave consequences for the usability of an orthography.
Bird, Steven
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

E.T.A. HOFFMANN’S «THE NUTCRACKER» AND THE EARLY GERMAN ROMANTICISM

open access: yesФилологический класс, 2016
The main problem of the paper is to consider E.T.A. Hoffmann’s fairy tale «The Nutcracker and the Mouse King» in the context of early German romanticism. The author makes a retrospective comparative analysis of the worldview expressed in Hoffmann’s fairy
doaj   +1 more source

Myth, Land, and History in the Poetry of James Clarence Mangan and Ernest Jones [PDF]

open access: yes, 2015
This essay discusses poetry associated with Irish nationalism and Chartism. Chartism’s eventual de facto leader, Ernest Jones, was an admired and prolific poet; as Irish poets including James Clarence Mangan were helping to forge a new Irish cultural ...
Rennie, Simon
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

K. Zabarylo – Researcher of German Romanticism [PDF]

open access: yes, 2008
Стаття ознайомлює з українським літературознавцем К. Забарилом та його неопублікованою критичною спадщиною. Досліджуються особливості сприйняття К. Забарилом філософсько-естетичної концепції німецького романтизму та специфіки її втілення в художніх ...
Muchka, Myroslava   +1 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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