Results 31 to 40 of about 1,244,792 (305)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Sport-Related National Pride in East and West Germany, 1992-2008

open access: yesSAGE Open, 2016
It is commonly assumed that international sport reinforces feelings of national pride and national identity. Using large-scale survey data from Germany, covering the period between 1992 and 2008, some unresolved key questions surrounding sportive ...
Henk Erik Meier, Michael Mutz
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

The Case of (East-) Germany

open access: yesJournal of Social Science Education, 2008
There has been a long tradition of thinking on Civic Education in Western Germany, mainly after World War II. Aims and means have been discussed thoroughly, experiences in teaching politics (the most common name for the school subject) have been reported
Sibylle Reinhardt
doaj   +1 more source

Perceived Threat, Reactive Identification, and Religious Change: Right-Wing Secularization in Germany, 1999–2017

open access: yesReligions, 2023
In this article, I integrate symbolic threat dynamics into a theoretical discussion of religious change. Specifically, this article demonstrates how symbolic threat can lead to increases in salient collective characteristics among members of the ...
Anthony Albanese
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Rising Wage Inequality in Germany [PDF]

open access: yes
The paper investigates the evolution of wages and wage inequality in Germany based on samples from the German Socio-Economic Panel (SOEP) 1984 to 2005.
Gernandt, Johannes, Pfeiffer, Friedhelm
core   +6 more sources

“ÜBERHOLEN OHNE EINZUHOLEN”? – SIMILARITIES AND DIFFERENCES BETWEEN SME SUPERVISORY BOARDS IN EAST AND WEST GERMANY

open access: yesDynamic Relationships Management Journal (DRMJ), 2018
This paper explores the similarities and differences between SME supervisory board structures and processes in East and West Germany. On the basis of two separate exploratory surveys it is shown that the East Germany companies are not lagging behind ...
Thomas Steger
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Changes in Birth Seasonality in East and West Germany, 1946-2017

open access: yesComparative Population Studies
Seasonal trends in fertility are found in several contexts and are affected by societal and environmental factors. This paper documents how birth seasonality in East and West Germany changed over time and, in particular, after 1989 and the onset of ...
Risto Conte Keivabu
doaj   +1 more source

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