Results 221 to 230 of about 272,234 (292)

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Assessing Climate Change Disclosure and Its Governance Drivers: Insights From the European Utilities Sector

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study aims to enhance academic understanding of the factors influencing the disclosure practices of climate change among European utility companies, specifically in the context of their sustainability reporting. The primary objective is to explore, through a multi‐theoretical framework, the governance drivers that significantly affect the
Cristina Boţa‐Avram, Adriana Tiron Tudor, Liana Stanca   +2 more
wiley   +1 more source

Speaking About Artificial Intelligence for Sustainability—How Employees’ Perception of Credibility Shapes Their Initial Attitudes Toward AI Adoption

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Companies increasingly claim to adopt artificial intelligence (AI) not only for economic but also for ecological and social purposes. However, in light of rising greenwashing, bluewashing, and ethics washing, the impact of the communicated rationale on employees' initial attitude toward AI introduction remains unclear.
Marco Baumgartner, Tobias Kopp, Regina Kempen, Steffen Kinkel   +3 more
wiley   +1 more source

Women's Leadership as a Driver of Small and Medium‐Sized Enterprises Sustainability and Green Transition: A Bibliometric and Systematic Review

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study combines a bibliometric analysis and a systematic literature review (SLR) to provide a comprehensive understanding of women's leadership and entrepreneurship within small and medium‐sized enterprises (SMEs) in the context of sustainability and the green transition.
Adriana Dima, Andreea Ileana Zamfir, Cosmin Dobrin, Monica Triculescu, Sorina Ioana Mişu, Ana Daria Pantelimon   +5 more
wiley   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

Heart failure therapy in patients with advanced cancer receiving specialized palliative care (EMPATICC trial). [PDF]

Eur Heart J
Anker MS, Mahabadi AA, Totzeck M, Tewes M, Khan MS, Mincu RI, Hendgen-Cotta UB, Michel L, Mathew B, Drescher O, Schuler M, Keller U, Rieger K, Ahn J, Bullinger L, Modest DP, Denecke C, Kretzler L, Ramer LV, Krug D, Landmesser U, Lehmann LH, Frey N, Bercker S, Laufs U, Böhm M, Mahfoud F, Merkely B, Diek M, Butler J, Veiser A, Heise T, Hellmich M, Placzek M, Friede T, Anker SD, Rassaf T.   +36 more
europepmc   +1 more source

Slip versus dilation tendency parameter space as a tool for prospecting structurally controlled geothermal systems in greenfield: insights from the greater Ruhr region

Deep Underground Science and Engineering, EarlyView.
This study highlights that with the static and time‐dependent evolution of slip versus dilation tendency parameter space, structurally controlled deep geothermal systems can be selected within areas of higher permeability and lower seismic hazard. Abstract Faults play a vital role in the Earth's hydraulic system by facilitating fluid flow when dilating
Michal Kruszewski, Alessandro Verdecchia, Oliver Heidbach, Rebecca M. Harrington, David Healy   +4 more
wiley   +1 more source

Bundibugyo virus-perspectives for the current outbreak. [PDF]

Npj Viruses
Hoenen T.
europepmc   +1 more source

Performance assessment of a potential underground thermal storage facility: Case study of the closed mine Prosper‐Haniel in the Ruhr coal mining area in Germany

Deep Underground Science and Engineering, EarlyView.
This study demonstrates the feasibility of an underground closed‐loop thermal storage facility at a post‐mining site, intended for seasonal heat energy storage. Its principal design shows water flow directions in winter and summer (1, 2), heat pumps (3), an upper water reservoir (4), and connecting pipes (5).
Dmytro Rudakov, Oleksandr Inkin
wiley   +1 more source

S1 guidelines of the German Society of Neurology for Viral Meningoencephalitis- AWMF Registration No.: 030-100. [PDF]

Neurol Res Pract
Meyding-Lamadé U, Craemer EM, Aydin K, Jacobi C, Wagner J, Pfausler B, Prange H, Schuchardt V, Mosthaf S, Mehling M, Klein M, Bassa B.   +11 more
europepmc   +1 more source