Results 121 to 130 of about 114,676 (292)

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas [PDF]

, 2004
Viviana Gismondi, Maurizio Meta, L Bonelli, Paolo Radice, Paola Sala, Lucio Bertario, Alessandra Viel, Mara Fornasarig, Arrigo Arrigoni, Mattia Gentile, Maurizio Ponz de Leòn, Luca Anselmi, Cristina Mareni, Paolo Bruzzi, Liliana Varesco   +14 more
openalex   +1 more source

Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome

Developmental Dynamics, EarlyView.
Abstract Background Gene transcription is crucial for embryo and postnatal development and is regulated by the Mediator complex. Mediator is comprised of four submodules, including the kinase submodule (CKM). The CKM consists of MED13, MED12, CDK8, and CCNC.
Anna K. Leinheiser, Timothy T. Nguyen, Kayla M. Henry, Mariela Rosales, Eric Van Otterloo, Chad E. Grueter   +5 more
wiley   +1 more source

Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas [PDF]

, 2013
Claire Palles, Jean‐Baptiste Cazier, Kimberley Howarth, Enric Domingo, Angela M. Jones, Peter Broderick, Zoe Kemp, Sarah L. Spain, Estrella Guarino, Israel Salguero, Amy L. Sherborne, Daniel Chubb, Luis G. Carvajal‐Carmona, Yusanne Ma, Kulvinder Kaur, Sara E. Dobbins, Ella Barclay, Maggie Gorman, Lynn Martin, Michal Kováč, Sean Humphray, Anneke Lucassen, Chris Holmes, David L. Bentley, Peter Donnelly, Jenny C. Taylor, Christos Petridis, Rebecca Roylance, Elinor J. Sawyer, David Kerr, Susan K. Clark, Jonathan M. Grimes, Stephen Kearsey, Huw Thomas, Gil McVean, Richard S. Houlston, Ian Tomlinson   +36 more
openalex   +1 more source

The Status and Emerging Developments in Laboratory Animal Science in Asia since 9th AFLAS Congress (2023) until 10th AFLAS Congress (2025)

Animal Models and Experimental Medicine, EarlyView.
Asian Federation of Laboratory Animal Science Associations (AFLAS)
wiley   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

GENE-09. MUTATION SIGNATURE ANALYSIS IN AN ULTRAHYPERMUTATED MEDULLOBLASTOMA PREDICTS UNDERLYING GERMLINE POLYMERASE PROOFREADING DEFICIENCY IN A CHILD WITH CLINICAL FEATURES OF CONSTITUTIONAL MISMATCH REPAIR DEFICIENCY SYNDROME [PDF]

, 2019
Holly Lindsay, Sarah Scollon, Jacquelyn Reuther, Horatiu Voicu, Surya P. Rednam, Kevin E. Fisher, Murali Chintagumpala, Donald W. Parsons, Adekunle M. Adesina, Sharon E. Plon, Angshumoy Roy   +10 more
openalex   +1 more source

Identification of Driver Epistatic Gene Pairs Combining Germline and Somatic Mutations in Cancer [PDF]

, 2023
Jairo Rocha, Jaume Sastre Tomas, Emilia Amengual-Cladera, Jessica Hernández-Rodríguez, Víctor José Asensio-Landa, Damián Heine‐Suñer, Emidio Capriotti   +6 more
openalex   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source