Results 121 to 130 of about 13,351 (224)
IJU Case Reports, Volume 6, Issue 1, Page 33-36, January 2023., 2023 Introduction In Lynch syndrome, urothelial cancer is the third most common cancer, following colorectal and endometrial cancers. Little is known, however, about the efficacy of immune checkpoint inhibitors in the treatment of metastatic urothelial cancer in Lynch syndrome.
Ryosuke Oki +7 more
wiley +1 more source
Ovarian Carcinoma In Situ With Germline BRCA1 Mutation and Loss of Heterozygosity at BRCA1 and TP53 [PDF]
, 2000 Bruce A. Werness
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Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin
IJU Case Reports, Volume 6, Issue 1, Page 37-40, January 2023., 2023 Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose) polymerase inhibitors such as olaparib.
Yoshiyuki Miyazawa +9 more
wiley +1 more source
Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16INK4A, P14ARF or cdk4 genes [PDF]
, 2000 Nadem Soufir +7 more
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Pan‐cancer analysis shapes the understanding of cancer biology and medicine
Cancer Communications, EarlyView.Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen +21 more
wiley +1 more source
Two novel germline mutations of the retinoblastoma gene (RB1) that show incomplete penetrance, one splice site and one missense [PDF]
, 2000 Hans Scheffer
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No evidence of germline PTEN mutations in familial prostate cancer [PDF]
, 2000 Matthew S. Forrest
openalex +1 more source