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Mutation induction in the mouse and human germline
Russian Journal of Genetics, 2016The review describes the effects of exposure to mutagens on mutation induction in human and mouse germlines. The results of studies that evaluated inductions of mutations in human families subjected to irradiation are presented and discussed. The effects of exposure to mutagens on mutation induction in the mouse germline are also considered. We analyze
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Germline Mutations as Cancer Drug Targets
Cancer DiscoveryAbstract Hereditary cancer syndromes are associated with causative pathogenic variants and clinical pathologies. Therapeutic advances have provided proof-of-concept for the actionability of the germline, whereas epidemiologic studies have identified pathogenic germline variants across tumor ...
Tin-Yun Tang +4 more
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Modern Developments in Germline Pharmacogenomics for Oncology Prescribing
Ca-A Cancer Journal for Clinicians, 2022Natalie Reizine, Peter H O'Donnell
exaly
Directional evolution in germline microsatellite mutations
Nature Genetics, 1996C R, Primmer +3 more
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Recent Progress in Lynch Syndrome and Other Familial Colorectal Cancer Syndromes
Ca-A Cancer Journal for Clinicians, 2018Patrick Boland +2 more
exaly