Results 231 to 240 of about 1,039,529 (408)

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu   +11 more
wiley   +1 more source

Causality extraction from medical text using Large Language Models (LLMs) [PDF]

open access: yesarXiv
This study explores the potential of natural language models, including large language models, to extract causal relations from medical texts, specifically from Clinical Practice Guidelines (CPGs). The outcomes causality extraction from Clinical Practice Guidelines for gestational diabetes are presented, marking a first in the field. We report on a set
arxiv  

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

open access: yesAdvanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

Smooth and shape-constrained quantile distributed lag models [PDF]

open access: yesarXiv
Exposure to environmental pollutants during the gestational period can significantly impact infant health outcomes, such as birth weight and neurological development. Identifying critical windows of susceptibility, which are specific periods during pregnancy when exposure has the most profound effects, is essential for developing targeted interventions.
arxiv  

Morbidity and Mortality in Small for Gestational Age Infants at 22 to 29 Weeks’ Gestation

open access: yesPediatrics, 2018
Nansi S. Boghossian   +3 more
semanticscholar   +1 more source

GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway

open access: yesAdvanced Science, EarlyView.
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou   +18 more
wiley   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han   +10 more
wiley   +1 more source

The Effect of Gestation Upon Lactation in The Dairy Cow

open access: bronze, 1924
A. C. Ragsdale   +2 more
openalex   +1 more source

Home - About - Disclaimer - Privacy