Results 171 to 180 of about 349,129 (310)

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Lifelong cognitive and motor outcomes after being born small for gestational age or with fetal growth restriction. [PDF]

World J Clin Pediatr
Ventura GC, Ryan H, Yu HN, Chand KK, Colditz PB, Wixey JA.   +5 more
europepmc   +1 more source

Gestational age

, 2018
Henry Knipe, Tariq Walizai, Jeremy Jones
openaire   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Gestational age amplifies the risk of airflow obstruction in adult smokers with asthma. [PDF]

ERJ Open Res
Konradsen JR, Stridsman C, Andersson N, Backman H, Vanfleteren LEGW, Ödling M.   +5 more
europepmc   +1 more source

Small for gestational age: Case definition & guidelines for data collection, analysis, and presentation of maternal immunisation safety data

Need for developing case definitions and guidelines for data collection, analysis, and presentation for small for gestational age (SGA) as an adverse event following maternal immunisation Small for gestational age (SGA) fetuses or newborns are those ...
Tapia, Milagritos D., Boghossian, Nansi S., Mousa, Hatem, Nisar, Muhammed Imran, Schlaudecker, Elizabeth P., Nesin, Mirjana, Pool, Vitali, Spiegel, Hans, Bardají, Azucena, Kochhar, Sonali, Black, Steven, Munoz, Flor M., Brighton Collaboration Small for Gestational Age Working Group, Khalil, Asma   +13 more
core  

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Association of Chorioamnionitis with Early and Late Neonatal Sepsis in Preterm Infants with Gestational Age < 32 Weeks. [PDF]

Diagnostics (Basel)
Babacheva E, Rallis D, Malakozi M, Tzafilkou K, Papacharalampous E, Chatziioannidis I, Liouliou P, Giannousiou E, Florou M, Tzitiridou-Chatzopoulou M, Tsakalidis C, Lithoxopoulou M.   +11 more
europepmc   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Chorionic Villi Sampling among Early and Late Gestational Age: Does Timing Affect Yield and Outcomes? [PDF]

AJP Rep
Kim J, Lao A, Rozenblyum A, Alamri L, Ludwigson A, Dunn T, Rebarber A, Lam-Rachlin J, Putra M, Chavez M, Rekawek P, Prasannan L.   +11 more
europepmc   +1 more source