Results 101 to 110 of about 1,409,358 (284)
Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics [PDF]
, 2015 Membrane transporters play an essential role in the transport of endogenous and exogenous compounds, and consequently they mediate the uptake, distribution, and excretion of many drugs. The clinical relevance of transporters in drug disposition and their
Knibbe, C.A.J. (Catherijne) +6 more
core +5 more sources
Advanced Science, EarlyView.Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng +9 more
wiley +1 more source
LifeThis retrospective cohort study evaluates the safety and efficacy of replacement therapy with regard to pregnancy outcomes in hemophilia carriers. Hemophilia carriers face elevated bleeding risks during pregnancy, necessitating meticulous management ...
Ebtisam Bakhsh
doaj +1 more source
Clinical features of infertile men carrying a chromosome 9 translocation
Open Medicine, 2019 Previous studies indicated that chromosome 9 translocations are involved in reduced male fertility and increased chance of miscarriage in the female partner.
Wang Ruixue +7 more
doaj +1 more source
Maternity Care and Consumer-Driven Health Plans [PDF]
, 2007 Compares out-of-pocket costs of maternity care under consumer-driven health plans (CDHP) to a traditional health insurance plan. Explores related factors including prenatal care coverage and unpredictability of costs for delivery and hospital ...
Alina Salganicoff +3 more
core
Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations [PDF]
, 2011 Dominantly acting loss-of-function mutations in the ABCC8/KCNJ11 genes can cause mild medically responsive hyperinsulinaemic hypoglycaemia (HH). As controversy exists over whether these mutations predispose to diabetes in adulthood we investigated the ...
Ellard, S +9 more
core +4 more sources
A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4
Advanced Science, EarlyView.This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He +11 more
wiley +1 more source
Genetic aspects of metabolic disorders in pregnant women with pathological weight gain
Regulatory Mechanisms in Biosystems, 2019 Polymorphism of the leptin receptor gene (LEPR) has been shown to be linked to obesity-related metabolic markers and phenotype. Therefore, we hypothesized that the Gln233Arg LEPR polymorphism is related to metabolic changes in pregnancy and the risk of ...
S. O. Ostafiichuk
doaj +1 more source
Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin-two cases. [PDF]
, 2019 BackgroundThe majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation.
Aydin, Elber Y +5 more
core +1 more source
Advanced Science, EarlyView.IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu +9 more
wiley +1 more source