Results 81 to 90 of about 1,409,358 (284)

Maternal genetic contribution to pre-pregnancy obesity, gestational weight gain, and gestational diabetes mellitus

Diabetology & Metabolic Syndrome, 2019
Introduction Pre-pregnancy obesity, gestational diabetes mellitus (GDM), and gestational weight gain (GWG) are associated with each other. This is the first study to investigate whether genetic variants were associated with having GDM, and whether ...
Selvihan Beysel, Nilnur Eyerci, Mustafa Ulubay, Mustafa Caliskan, Muhammed Kizilgul, Merve Hafızoğlu, Erman Cakal   +6 more
doaj   +1 more source

TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus

Metabolism Open, 2020
Objective: There is sparse evidence for the impact of gene-diet interaction on gestational diabetes mellitus (GDM) onset. Recent findings have shown that late first-trimester high adherence to a Mediterranean diet (MedDiet) pattern is associated with a ...
Ana Barabash, Johanna D. Valerio, Nuria Garcia de la Torre, Inés Jimenez, Laura del Valle, Verónica Melero, Carla Assaf-Balut, Manuel Fuentes, Elena Bordiu, Alejandra Durán, Miguel A. Herraiz, Nuria Izquierdo, María J. Torrejón, Paz de Miguel, Isabelle Runkle, Miguel A. Rubio, Alfonso L. Calle-Pascual   +16 more
doaj   +1 more source

Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks

BMC Pregnancy and Childbirth, 2021
Background Prevalence of neonatal microcephaly in populations without Zika-epidemics is sparse. The study aimed to report baseline prevalence of congenital microcephaly and its relationship with prenatal factors in an area at risk of Zika outbreak ...
Songying Shen, Wanqing Xiao, Lifang Zhang, Jinhua Lu, Anna Funk, Jianrong He, Si Tu, Jia Yu, Li Yang, Arnaud Fontanet, Wei Bao, Kar Keung Cheng, Xiu Qiu   +12 more
doaj   +1 more source

Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding. [PDF]

, 2016
Fragile X premutation alleles have 55-200 CGG repeats in the 5' UTR of the FMR1 gene. Altered zinc (Zn) homeostasis has been reported in fibroblasts from >60 years old premutation carriers, in which Zn supplementation significantly restored Zn ...
Gane, Louise W, Giulivi, Cecilia, Hagerman, Randi, Napoli, Eleonora, Ross-Inta, Catherine, Smilowitz, Jennifer T, Song, Gyu, Tassone, Flora, Wong, Sarah   +8 more
core   +3 more sources

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.

PLoS ONE
ObjectiveTo investigate the associations of Insulin-like growth factor-II (IGF2) gene, Insulin-like growth factor-II receptor (IGF2R) gene and Insulin-like growth factor-II binding protein 2 (IGF2BP2) gene polymorphisms with the susceptibility to ...
Wei Li, Lu She, Muyu Zhang, Mei Yang, Wenpei Zheng, Hua He, Ping Wang, Qiong Dai, Zhengtao Gong   +8 more
doaj   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Bacterial infections in neonates following mupirocin-based MRSA decolonization: A multicenter cohort study [PDF]

, 2017
OBJECTIVETo characterize the risk of infection after MRSA decolonization with intranasal mupirocin.DESIGNMulticenter, retrospective cohort study.SETTINGTertiary care neonatal intensive care units (NICUs) from 3 urban hospitals in the United States ...
Bryant, Kristina, Elward, Alexis, Lessler, Justin, Milstone, Aaron M, Pierce, Rebecca   +4 more
core   +3 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Management of pregnancy in women with monogenic diabetes due to mutations in GCK, HNF1A and HNF4A genes

Frontiers in Genetics
Women with maturity-onset diabetes of the young (MODY) need tailored antenatal care and monitoring of their offspring. Each MODY subtype has different implications for glycaemic targets, treatment choices and neonatal management.
M. T. Crowley, B. Paponette, S. Bacon, M. M. Byrne   +3 more
doaj   +1 more source