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Ultra-High-Risk Gestational Choriocarcinoma of the Ovary Associated with Ectopic Pregnancy [PDF]

Current Oncology, 2023
Gestational choriocarcinoma of the ovary is an exceptionally rare and highly aggressive tumor. Preoperative diagnosis of extrauterine choriocarcinoma is difficult due to nonspecific clinical presentation and its resemblance to ectopic pregnancy.
Eva Pavla Malovrh, Nuša Lukinovic, Monika Sobočan   +2 more
exaly   +4 more sources

Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma [PDF]

Biomedicines, 2021
The human placenta shares properties with solid tumors, such as rapid growth, tissue invasion, cell migration, angiogenesis, and immune evasion. However, the mechanisms that drive the evolution from premalignant proliferative placental diseases—called hydatidiform moles—to their malignant counterparts, gestational choriocarcinoma, as well as the ...
Jonathan Lopez, Christophe Battail, Fabienne Allias   +2 more
exaly   +8 more sources

Diagnostic pitfall in primary cervical gestational choriocarcinoma: a case report [PDF]

Frontiers in Oncology
Choriocarcinoma belongs to a group of highly aggressive malignant gestational trophoblastic neoplasms. Choriocarcinoma is classified into two types based on the origin: a gestational type that arises following a normal or abnormal pregnancy and a non ...
Jiayu Shi, Ping Chen
doaj   +2 more sources

Spontaneous bleeding from an unusual renal mass: A case of gestational choriocarcinoma related to previous pregnancy over a decade earlier [PDF]

Urology Case Reports, 2021
Gestational choriocarcinoma is an uncommon trophoblastic malignancy, occurring in females after pregnancy, which is rarely encountered by urologists. It can be rapidly progressive, however metastases to other organs can occur after a prolonged latency ...
Yilu He, Varun Bhoopathy, David Habashy, Stuart Adams, Steve P. McCombie, Mohan Arianayagam   +5 more
doaj   +2 more sources

A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy

Taiwanese Journal of Obstetrics and Gynecology, 2022
Objective: To report the rare case of gestational primary ovarian choriocarcinoma coexistent with intrauterine pregnancy, successfully treated with surgery and systemic chemotherapy. We also describe the utility of short tandem repeat (STR) genotyping in
Hiroyuki Shigeta
exaly   +3 more sources

Downregulation of the gli transcription factors regulator Kif7 facilitates cell survival and migration of choriocarcinoma cells. [PDF]

PLoS ONE, 2014
The kinesin protein Kif7 has been recognized as an integral component of hedgehog signalling. Aberrant activation of hedgehog signalling has been implicated in many human solid tumours.
Joanna Ho, Yanan Du, Oscar Gee-Wan Wong, Michelle K Y Siu, Karen K L Chan, Annie N Y Cheung   +5 more
doaj   +4 more sources

Gestational choriocarcinoma presenting with hemorrhagic venous infarct and multiple lung metastases: A case report [PDF]

Radiology Case Reports
Choriocarcinoma is a rare and aggressive form of gestational trophoblastic disease with a high potential for metastasis. We report the case of a 31-year-old female who presented with severe headaches, left-sided weakness, and speech difficulties.
Bakar Ali Adam, MD, Yahye Garad Mohamed, MD, Mohamed Sheikh Hassan, MD, Nor Osman Sidow, MD, Mohamed osman omar jeele, MD, Abdulkadir Ahmed Mohamed, MD, Mohamed Farah Osman Hidig, MD, Abdiwahid Ahmed Ibrahim, MD, Abdikadir Mohamed Dirie, MD, Ahmed Issak Hussein, MD, Mohamed Omar Hassan, MD   +10 more
doaj   +2 more sources

A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab

Taiwanese Journal of Obstetrics and Gynecology, 2023
Objective: Gestational choriocarcinoma is a gestational trophoblastic neoplasia (GTN) that originates from abnormal trophoblast proliferation. Although chemotherapy is effective for choriocarcinoma, personalized treatment becomes essential when patients ...
Kaoru Niimi, Eiko Yamamoto, Yukari Oda   +2 more
exaly   +3 more sources

A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations [PDF]

BMC Cancer, 2019
Background Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over ...
Philip Savage, David Monk, Jose R. Hernandez Mora, Nick van der Westhuizen, Jennifer Rauw, Anna Tinker, Wendy Robinson, Qianqian Song, Michael J. Seckl, Rosemary A. Fisher   +9 more
doaj   +2 more sources

Short tandem repeats genotyping of gestational choriocarcinoma – our experiences

Taiwanese Journal of Obstetrics and Gynecology
Objective: This short communication demonstrates how short tandem repeat genotyping can identify the origin of gestational choriocarcinoma. Materials and methods: The origin of gestational choriocarcinoma in our three cases was determined using the short
Robert Petrović, Ludovít Danihel, Józef Sufliarsky   +2 more
exaly   +3 more sources