Results 31 to 40 of about 6,686 (177)

Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. [PDF]

, 1996
The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors.
Abrams, JS, Corry, DB, Fisher, SJ, Litton, MJ, Locksley, RM, Roth, I   +5 more
core   +1 more source

Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR [PDF]

, 2013
BACKGROUND: H19 is a paternally imprinted gene that has been shown to be highly expressed in the trophoblast tissue. Results from previous studies have initiated a debate as to whether noncoding RNA H19 acts as a tumor suppressor or as a tumor promotor ...
Dan Zhao, Jian Han, Jian-Xin Guo, Kai Chang, Li Li, Li-Li Yu, Lin-Shan Lu, Ming Chen, Ping Yi, Yao-Hua Yan, Ying-Ru Zheng, Yuan-Guo Zhou   +11 more
core   +1 more source

AMHR2 mutation in persistent Müllerian duct syndrome: A case of transverse testicular ectopia

UroPrecision, Volume 4, Issue 1, Page 64-68, March 2026.
Abstract Backgroud Persistent Müllerian duct syndrome (PMDS) is a rare condition characterized by the persistence of Müllerian duct structures in genotypic and phenotypic males. Case Presentation We present the case of a 4‐month‐old male with PMDS who presented with transverse testicular ectopia. The patient underwent diagnostic laparoscopic orchiopexy
Hangcheng Fu, Weijing Huang, Jeffrey T. White   +2 more
wiley   +1 more source

MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1 [PDF]

, 2013
Background: Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression.
Chiu, PCN, Lam, KKW, Lee, CL, Leung, CON, Pang, RTK, Ye, TM, Yeung, WSB   +6 more
core   +2 more sources

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Identification and characterisation of NANOG+/OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines [PDF]

, 2018
Treatment of gestational trophoblastic diseases (GTD) involves surgery, radiotherapy and chemotherapy. Although, these therapeutic approaches are highly successful, drug resistance and toxicity remain a concern for high risk patients.
Aplin, Audus, Bajpai, Bellet, Berkowitz, Clarke, Fisher, Fowden, Frank, Gey, Heeschen, Huppertz, Johnson, Kwon, Lala, Lenz, Loke, Machado, Markovic, Qin, Rao, Rofstad, Seckl, Sessa, Taichman, Tang, Tsao, Weinberg, Yu, Yuan   +29 more
core   +2 more sources

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse

The Journal of Physiology, Volume 604, Issue 1, Page 566-581, 1 January 2026.
Abstract figure legend Maternal obesity induces systemic inflammation and high insulin and leptin levels, potentially promoting hepcidin release into circulation and thus iron sequestration in specific tissue compartments. This results in low iron availability in the mother with potential detrimental effects on the fetus, including hypoxia.
Adriana Córdova‐Casanova, Isabella Inzani, Antonia Hufnagel, Dino A Giussani, Denise S. Fernandez‐Twinn, Susan E Ozanne   +5 more
wiley   +1 more source

Abdominal Hysterectomy Under Thoracic Epidural Anesthesia for Complete Molar Pregnancy in a Patient With Atypical Preeclampsia and Hyperthyroidism in a Resource‐Limited Setting: Case Report and Literature Review

Case Reports in Anesthesiology, Volume 2026, Issue 1, 2026.
Background Hydatidiform mole is a rare gynecological disease arising from trophoblastic tissue. There is no standard anesthetic management for patients undergoing major abdominal surgery; the decision may be based on preoperative patient status, the presence of coexisting illnesses, the risk of aspiration, and the availability of advanced equipment ...
Mesay Milkias, Semagn Mekonnen, Fikru Milkiyas, Mebratu Kebede, Nigatu Tilahun, Srijoni Sengupta   +5 more
wiley   +1 more source

Headache and pregnancy. a systematic review [PDF]

, 2017
This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child during pregnancy and breastfeeding, headache ...
A. Negro, A. Terrin, B. Raffaelli, D. D. Mitsikostas, on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS), R. Ornello, S. Khan, T. A. Ivanova, U. Reuter, Z. Delaruelle   +9 more
core   +1 more source