Results 1 to 8 of about 8 (8)

Activity of Antibiotics and Potential Antibiofilm Agents against Biofilm-Producing Mycobacterium avium-intracellulare Complex Causing Chronic Pulmonary Infections

Antibiotics, 2022
Nontuberculous mycobacteria (NTM) cause lung infections in patients with underlying pulmonary diseases (PD). The Mycobacteriumavium-intracellulare complex (MAC) is the most frequently involved NTM.
Elena Portell-Buj, Cecibel González-Criollo, Alexandre López-Gavín, Mariana Fernández-Pittol, Maria Antònia Busquets, Joan Estelrich, Montserrat Garrigó, Marc Rubio, Griselda Tudó, Julian Gonzalez-Martin   +9 more
doaj   +1 more source

Structure‐Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti‐Alzheimer's Agents

ChemMedChem, Volume 17, Issue 13, July 5, 2022., 2022
Epigenetic modifications: A structure‐based virtual screen led to the identification of new scaffolds as potent G9a inhibitors. These promising hits exhibited better in silico profiles, IC50 values, and BBB permeability than currently published inhibitors for G9a.
Aina Bellver‐Sanchis, Bhanwar Singh Choudhary, Júlia Companys‐Alemany, Sukanya, Pedro A. Ávila‐López, Antón Leandro Martínez Rodríguez, Jose Manuel Brea Floriani, Ruchi Malik, Mercè Pallàs, Belén Pérez, Christian Griñán‐Ferré   +10 more
wiley   +1 more source

Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse

Annals of Clinical and Translational Neurology, Volume 6, Issue 9, Page 1815-1824, September 2019., 2019
Abstract Objective To determine the cutoffs that optimized the agreement between 18F‐Florbetapir positron emission tomography (PET) and Aβ1‐42, Aβ1‐40, tTau, pTau and their ratios measured in cerebrospinal fluid (CSF) on the LUMIPULSE G600II instrument, we quantified the levels of these four biomarkers in 94 CSF samples from participants of the Sant ...
Daniel Alcolea, Jordi Pegueroles, Laia Muñoz, Valle Camacho, Diego López‐Mora, Alejandro Fernández‐León, Nathalie Le Bastard, Els Huyck, Alicia Nadal, Verónica Olmedo, Frederic Sampedro, Victor Montal, Eduard Vilaplana, Jordi Clarimón, Rafael Blesa, Juan Fortea, Alberto Lleó   +16 more
wiley   +1 more source

Non-tuberculous mycobacteria isolates from patients with chronic pulmonary disease and no epidemiological relationship show sequence clusters through whole-genome sequencing

Frontiers in Microbiology
ObjectivesThis study aimed to investigate the genomic epidemiology of slow-growing mycobacteria (SGM) isolates from patients with bronchiectasis through whole-genome sequencing (WGS) and assess various bioinformatic tools to establish relationships ...
Marc Rubio, Marc Rubio, Mariana Fernandez-Pittol, Mariana Fernandez-Pittol, Mariana Fernandez-Pittol, Sara Batista, Sara Batista, Sara Batista, Diego Martínez, Lorena San Nicolas, Elena Portell-Buj, Elena Portell-Buj, Elena Portell-Buj, Maria Antònia Busquets, Maria Antònia Busquets, Joan Estelrich, Joan Estelrich, Julian Gonzalez-Martin, Julian Gonzalez-Martin, Julian Gonzalez-Martin, Julian Gonzalez-Martin, Ferran Navarro, Ferran Navarro, Ferran Navarro, Griselda Tudó, Griselda Tudó, Griselda Tudó, Montserrat Garrigó, Montserrat Garrigó, Montserrat Garrigó   +29 more
doaj   +1 more source

Characterization of Ligand Binding in Human Serum Albumin from Atomistic Energy Transfer Simulations

Small Methods, Volume 9, Issue 12, December 1, 2025.
Förster resonance energy transfer (FRET) is used to identify binding sites and characterize ligand coordination modes by combining fluorescence spectroscopy with efficient atomistic simulations beyond Förster theory. The protocol is validated on known binders of human serum albumin and applied to study the binding of a set of fluorescent fragments ...
Özge Ergün, Andrea Bertran‐Mostazo, Elena Cubero, Carles Galdeano, Carles Curutchet   +4 more
wiley   +1 more source

ISEV2018 abstract book

, 2018
Journal of Extracellular Vesicles, Volume 7, Issue S1, April 2018.
Clotilde Théry, Kenneth Witwer
wiley   +1 more source

Mechanical Strain‐Controlled Aromaticity in Cyclo[n]Carbons

Chemistry – A European Journal, Volume 31, Issue 45, August 13, 2025.
Mechanical strain can influence the (anti)aromaticity of C16 and C18 cyclocarbons. While uniaxial tension has a minor weakening effect, radial expansion leads to an almost complete loss of aromaticity in both systems. Radial contraction, especially in C18, significantly enhances aromaticity, offering a strategy for designing more stable cyclocarbons in
O. A. Stasyuk, C. Curutchet, A. J. Stasyuk   +2 more
wiley   +1 more source

First‐principles simulations of the fluorescence modulation of a COX‐2‐specific fluorogenic probe upon protein dimerization for cancer discrimination

Protein Science, Volume 34, Issue 1, January 2025.
Abstract Cyclooxygenase‐2 (COX‐2) plays a crucial role in inflammation and has been implicated in cancer development. Understanding the behavior of COX‐2 in different cellular contexts is essential for developing targeted therapeutic strategies. In this study, we investigate the fluorescence spectrum of a fluorogenic probe, NANQ‐IMC6, when bound to the
Álex Pérez‐Sánchez, Carles Curutchet, Àngels González‐Lafont, José M. Lluch   +3 more
wiley   +1 more source