Results 61 to 70 of about 85,876 (312)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

« Faire intimité » en migration

Sociologies
Drawing on a literature review of diverse conceptions of intimacy in migration, this introduction underscores that intimacy, while inherently tied to a sense of interiority, is shaped by social norms, institutional directives and relational dynamics.
Audran Aulanier, Laura Odasso
doaj   +1 more source

Cortical Motor Organization, Mirror Neurons, and Embodied Language: An Evolutionary Perspective

Biolinguistics, 2012
The recent conceptual achievement that the cortical motor system plays a crucial role not only in motor control but also in higher cognitive functions has given a new perspective also on the involvement of motor cortex in language perception and ...
Leonardo Fogassi, Pier Francesco Ferrari
doaj   +1 more source

Hand Gesture Controlled Robotic Arm

, 2022
Tanishjeet Singh, V. S Krushnasamy, Sadaf Zubear, Nadir Nawab, Ankit Kumar   +4 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Microcontroller Unit-Based Gesture Recognition System

Machines
This article describes the design, construction, and programming of a microcontroller-based system, which uses hand gestures with machine learning algorithms to control an unmanned aerial vehicle (UAV).
Jakub Grabarczyk, Agnieszka Lazarowska
doaj   +1 more source

Intentional Presentation of Objects in Cooperatively Breeding Arabian Babblers (Turdoides squamiceps)

Frontiers in Ecology and Evolution, 2019
The emergence of intentional communication and the intentional presentation of objects have been highlighted as important steps in the ontogeny of cooperative communication in humans.
Yitzchak Ben Mocha, Yitzchak Ben Mocha, Yitzchak Ben Mocha, Simone Pika, Simone Pika   +4 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source