Results 181 to 190 of about 754,617 (236)

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Human-Delivered Conversation Versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States: Quasi-Experimental Studies.

J Med Internet Res
Kim DD, Zhang J, Sagae K, Devon HA, Hoffmann TJ, Rountree L, Fukuoka Y.   +6 more
europepmc   +1 more source

Patient perspectives. [PDF]

Lancet Reg Health West Pac
Crook CR, Thompson SC.
europepmc   +1 more source

Report of the GCSE English and Mathematics Project (Phase 2) : February-June 2013, end of project report/evaluation [PDF]

, 2013

core  

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

How do we put meaning into meaningful benefit? Perspectives from the lived experience. [PDF]

Alzheimers Dement (N Y)
Paulsen R, Romano CD, Frangiosa T, Mordin M, Dardis GJ, DiBenedetti D, Petersen RC, Cummings JL.   +7 more
europepmc   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

"I'm Afraid to Put Any More of It Into My Body": COVID-19 Vaccination and Booster Barriers and Facilitators Among People with HIV in South Carolina. [PDF]

AIDS Behav
Garrett C, N'Diaye A, Qiao S, Li X.
europepmc   +1 more source

The importance of self-care: How the ‘Getting Sorted’ programme helps young people manage their diabetes. [PDF]

, 2013
Clarke, S, Kime, NH, Webster, E
core  

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source