Results 141 to 150 of about 122,015 (230)

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

open access: yesAdvanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang   +8 more
wiley   +1 more source

Improving High‐Temperature Operational Stability of Inverted Perovskite Solar Cells Through MXene Heat‐Dissipating Layers

open access: yesAdvanced Science, EarlyView.
MeO‐2PACz‐functionalized MXene nanosheets create a thermally conductive buried interface in inverted perovskite solar cells. The interface improves heat spreading, suppresses defects and ion migration, and strengthens charge extraction, extending T80 at 65°C from 141 to 687 h while maintaining competitive efficiency.
Masoud Karimipour   +12 more
wiley   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian   +21 more
wiley   +1 more source

Green's Functions of Non‐Hermitian Systems at Exceptional Deficiency

open access: yesAdvanced Science, EarlyView.
We analyze the responses of a non‐Hermitian lattice system under the condition of exceptional deficiency (ED), when all bands in the system are formed by exceptional points. Using the frequency domain, we identify novel steady‐state responses that root in the broadband super‐Lorentzian Green's function (GF).
Congwei Lu, Guancong Ma
wiley   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

open access: yesAdvanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge   +6 more
wiley   +1 more source

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