Results 171 to 180 of about 520,090 (317)

GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon

, 2003
Trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) is central to its function, with the most common mutation, ΔF508, resulting in abnormal processing and trafficking.
Oceandy, D (15514022), Schreiber, R (15513980), Wainwright, B (15513965), McMorran, BJ (15513950), Kunzelmann, K (15513968)   +4 more
core  

Spectral scanning and fluorescence lifetime imaging microscopy (FLIM) enable separation and characterization of C. elegans autofluorescence in the cuticle and gut

Biology Open
Heino J. Hulsey-Vincent, Elizabeth A. Cameron, Caroline L. Dahlberg, Domenico F. Galati   +3 more
doaj   +1 more source

A cytosolic IF1 reporter enables real-time visualization of severe mitochondrial membrane damage. [PDF]

J Cell Biol
Gao E, Guan L, Zhang K, Qi S, Xu J, Zhang J, Zhu T, Yang B, Yang C, Miska E, Zhang M, Xu S.   +11 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Stress-induced MAPK (SIMK)-dependent organization of microtubules in alfalfa. [PDF]

Mol Hortic
Hlaváčková K, Ovečka M, Šamajová O, Šamaj J.   +3 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Tracheal terminal cells of <i>Drosophila</i> are immune privileged to maintain their Foxo-dependent structural plasticity. [PDF]

Elife
Bossen J, Fritz L, Raveendran R, Shi L, He J, Roeder T.   +5 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Coordinated Pre- and Postsynaptic Protein Dynamics Underlie Rapid Sema4D-Induced Inhibitory Synapse Assembly. [PDF]

eNeuro
Pranske Z, Paradis S.
europepmc   +1 more source

Illuminating GFP [PDF]

Nature Reviews Neuroscience, 2000
openaire   +1 more source