Results 211 to 220 of about 147,929 (284)

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Understanding the Progression of Chronic Kidney Disease in Cats: From Pathophysiology to Emerging Biomarkers. [PDF]

Vet Sci
Rosa S, Silvestre-Ferreira AC, Martins R, Queiroga FP.   +3 more
europepmc   +1 more source

Heterogeneous regulation of fibroblast growth factor 23 in acute kidney injury, chronic kidney disease, and polycystic kidney disease: mechanisms, diagnostic utility, and clinical implications. [PDF]

Front Mol Biosci
Hu X, Yang B, Chen H, Min M, Liu N, Xue C.   +5 more
europepmc   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

The diagnostic value of uromodulin protein measurement in autosomal dominant tubulointerstitial kidney disease due to uromodulin mutation (ADTKD-UMOD): serum or urine? [PDF]

BMC Nephrol
Onoe T, Kawano M, Mizushima I, Ito K, Kawahara H, Matsuno T, Hara S, Yamada K, Zoshima T, Goto-Hirano K, Daimon S, Muramoto H, Ubara Y, Mitobe M, Tsuruta H, Kishimoto N, Imura J, Mori T, Iwata Y.   +18 more
europepmc   +1 more source

Octreotide long-acting release in the treatment of autosomal dominant polycystic kidney disease: a meta-analysis. [PDF]

Front Endocrinol (Lausanne)
Jin M, Shi P, Yu Y.
europepmc   +1 more source

Real‐world efficacy and toxicity of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma according to IMDC risk criteria—A multi‐center retrospective analysis on behalf of the GUARDIANS group

International Journal of Cancer, Volume 158, Issue 9, Page 2440-2451, 1 May 2026.
What's new? The combination of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma has demonstrated durable response and tolerability in clinical trials. However, inclusion criteria for clinical studies are restrictive, and patients in the real‐world setting tend to have more comorbidities.
Hendrik Dinkel, Linus Materna, Ramona Stelmach, Stefanie Zschäbitz, Stephanie Neuberger, Can D. Aydogdu, Jozefina Casuscelli, Timo Egenolf, Matteo Silberg, Julie Steinestel, Arne Strauss, Florian Kirchhoff, Marit Ahrens, Pia Paffenholz, Richard Cathomas, Berna C. Özdemir, Christopher Gossler, Philipp Ivanyi, Marc Rehlinghaus, Thomas Hilser, Viktor Grünwald, Katrin Schlack   +21 more
wiley   +1 more source

Association Between Body Mass Index and Hematotoxicity in Gynecological Cancer Patients Receiving Paclitaxel-Carboplatin Therapy: A Retrospective Study. [PDF]

Cureus
Obana T, Fujimoto S, Fujiwara K, Takegami M, Nakai H, Nishida S, Nagai N, Tsubaki M.   +7 more
europepmc   +1 more source

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

Genetic Prediction of Kidney Function: Why Measured GFR Matters. [PDF]

Kidney Int Rep
Khan A.
europepmc   +1 more source