Results 141 to 150 of about 15,759 (257)

Post‐Trial Responsibilities for Participants Implanted With Neurosurgical Devices: A Qualitative Study

Bioethics, EarlyView.
ABSTRACT The issue of post‐trial responsibility is about what is owed to research participants after a clinical trial ends, who is responsible, and how long this responsibility must endure. Despite two decades of international guidance on this issue, research involving novel high‐risk interventions—such as implantable neurotechnologies—raises ...
Nathan Higgins, Adrian Carter, John Gardner   +2 more
wiley   +1 more source

Adenoid ameloblastoma of the mandible: report of a new case of a distinct type of odontogenic neoplasms. [PDF]

BMC Oral Health
Abou Madawi N, Abdou A, El Bahey N, Moussa M.   +3 more
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Sustained low micromolar hydrogen peroxide exposure induces sequential red blood cell dysfunction. [PDF]

Front Physiol
Baek JH, Williams MC, Jana S, Zhang X, D'Agnillo F.   +4 more
europepmc   +1 more source

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Primary central nervous system lymphoma of the third ventricle: Diagnostic pitfalls, the "Ghost Tumor" phenomenon, and steroid-induced complications. [PDF]

Surg Neurol Int
Danevych O, Mumliev A, Guk M, Solovey M, Iegorova K, Ukrainets O, Chukov A, Lisianyi A.   +7 more
europepmc   +1 more source

Mass Mobilising for Climate Action: A Member‐Driven Innovation Process in a Nongovernmental Organisation

Creativity and Innovation Management, EarlyView.
ABSTRACT Environmental organisations (EOs) are not‐for‐profit organisations that contribute to responsible innovation (RI) efforts to mitigate the climate crisis as central catalysts in society. While the RI discourse in management research acknowledges that collaboration between a broad variety of actors is necessary to foster climate action, so far ...
Ida Raunkjær, Patricia Wolf, Szabolcs Dezso Fabian   +2 more
wiley   +1 more source

Biomimetic Targeted Drug Delivery for Liver Failure in Abdominal Sepsis: Focus on Autologous Erythrocyte Ghosts. [PDF]

Int J Mol Sci
Berikkhanova K, Inuwa I, Taigulov E, Kozhakhmetov S, Bikhanov N, Omarbekov A, Berikkhanova G, Sultan Y, Jibo AG, Abdrakhmanova S, Zhakiyanova Z, Tanysheva G, Zhumadilov Z.   +12 more
europepmc   +1 more source

Mental health contacts and referrals of children and young people in England, 2016–2021: An epidemiological study and comparison of young people who have received protective and care interventions and their peers

Child and Adolescent Mental Health, EarlyView.
Background In England, 18% of children and young people (CYP) experience clinical levels of mental health difficulties. CYP who are involved in children's social care, either receiving in‐home care (i.e. child protection plans; CPP) or out‐of‐home care (i.e. children looked after; CLA), may experience higher prevlance than peers.
Barry Coughlan, Julia Mannes, Nicole Marshall, Tessa Morgan, Tamsin J. Ford, Francesca Crozier‐Roche, David Graham, Taliah Drayak, Jack Smith, Luke Geoghegan, Matt Woolgar, Rick Hood, Robbie Duschinsky   +12 more
wiley   +1 more source