Results 171 to 180 of about 15,759 (257)

Ion binding sites and intermediate domain closure induced by D‐serine in the GluD1 ligand‐binding domain

open access: yesThe FEBS Journal, EarlyView.
GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen   +4 more
wiley   +1 more source

Novel and emerging skin carcinomas and adnexal tumours

open access: yesHistopathology, EarlyView.
The present review aims to provide an overview of the main emerging skin epithelial tumours, with particular emphasis on salivary gland analogue sweat gland tumours and poorly differentiated carcinomas. Epidermal and adnexal tumours of the skin constitute a complex and heterogeneous group of neoplasms, with distinct morphology and behaviour.
Thibault Kervarrec   +2 more
wiley   +1 more source

High-throughput high content quantification of HIV-1 viral infectious output. [PDF]

open access: yesPLoS One
LuPone T   +7 more
europepmc   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

open access: yesInternational Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller   +11 more
wiley   +1 more source

Single‐Cell Atlas Reveals Neutrophil Heterogeneity in Hypervirulent Klebsiella pneumoniae Infection‐Induced Sepsis

open access: yesImmunology, EarlyView.
The roles of distinct lung neutrophil compartments involved in hvKp infection remain poorly understood. Here, utilising single‐cell RNA sequencing, we identified four neutrophil subsets in the lungs of hvKp‐infected mice: N1, N2, N3a, and N3b, which were organised along a maturation trajectory.
Xiang Fang   +7 more
wiley   +1 more source

Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk

open access: yesJournal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 460-476, April 2025.
Psychosis in children and adolescents has been studied on a spectrum from (common) psychotic experiences to (rare) early‐onset schizophrenia spectrum disorders. This research review looks at the state‐of‐the‐art for research across the psychosis spectrum, from evidence on psychotic experiences in community and clinical samples of children and ...
Ian Kelleher
wiley   +1 more source

The Last Line

open access: yes
Critical Quarterly, EarlyView.
Beci Carver
wiley   +1 more source

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