Results 291 to 300 of about 93,938 (325)
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Peptides, 2019
Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone-releasing and orexigenic activities by binding to specific receptors in the brain.
Takeshi Tokudome +3 more
openaire +3 more sources
Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone-releasing and orexigenic activities by binding to specific receptors in the brain.
Takeshi Tokudome +3 more
openaire +3 more sources
Journal of Medicinal Chemistry, 2018
The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors.
Céline M'kadmi +15 more
semanticscholar +1 more source
The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors.
Céline M'kadmi +15 more
semanticscholar +1 more source
2007
A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone.
Patric J.D. Delhanty +4 more
openaire +3 more sources
A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone.
Patric J.D. Delhanty +4 more
openaire +3 more sources
BioFactors, 2013
AbstractGhrelin is a gut‐derived peptide hormone, first isolated from the stomach. Ghrelin was initially characterized as a growth hormone (GH) secretagogue, but it plays a more important role as a potent orexigen and modulator of whole‐body energy homeostasis. Ghrelin itself is closely regulated by metabolic status.
Johannes P.T.M. van Leeuwen +2 more
openaire +3 more sources
AbstractGhrelin is a gut‐derived peptide hormone, first isolated from the stomach. Ghrelin was initially characterized as a growth hormone (GH) secretagogue, but it plays a more important role as a potent orexigen and modulator of whole‐body energy homeostasis. Ghrelin itself is closely regulated by metabolic status.
Johannes P.T.M. van Leeuwen +2 more
openaire +3 more sources
Brain accessibility delineates the central effects of circulating ghrelin
Journal of neuroendocrinology, 2019Ghrelin is a hormone produced in the gastrointestinal tract that acts via the growth hormone secretagogue receptor. In the central nervous system, ghrelin signalling is able to recruit different neuronal targets that regulate the behavioural ...
M. Perelló +5 more
semanticscholar +1 more source
Metabolic Syndrome and Related Disorders, 2006
Ghrelin was discovered for its ability to bind the growth hormone secretagogue receptor (GHSR1a) and stimulate growth hormone release. However, much research conducted with this novel stomach hormone is focused on proposed roles for it to participate in regulating energy balance.
Mark L. Heiman, Derrick R. Witcher
openaire +3 more sources
Ghrelin was discovered for its ability to bind the growth hormone secretagogue receptor (GHSR1a) and stimulate growth hormone release. However, much research conducted with this novel stomach hormone is focused on proposed roles for it to participate in regulating energy balance.
Mark L. Heiman, Derrick R. Witcher
openaire +3 more sources
Current Opinion in Clinical Nutrition & Metabolic Care, 2017
A compromised autophagy is associated with the onset of obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases. Our aim is to review the potential role of ghrelin, a gut hormone involved in energy homeostasis, in the regulation of autophagy.In the recent years, it has been demonstrated that autophagy ...
Amaia Rodríguez +2 more
openaire +2 more sources
A compromised autophagy is associated with the onset of obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases. Our aim is to review the potential role of ghrelin, a gut hormone involved in energy homeostasis, in the regulation of autophagy.In the recent years, it has been demonstrated that autophagy ...
Amaia Rodríguez +2 more
openaire +2 more sources
Current Opinion in Lipidology, 2015
The increasing prevalence of metabolic syndrome and the consequent cardiovascular diseases has stimulated an active search for novel risk factors. The hormones regulating energy balance are of special interest as potential risk factor indicators of cardiovascular diseases.
openaire +3 more sources
The increasing prevalence of metabolic syndrome and the consequent cardiovascular diseases has stimulated an active search for novel risk factors. The hormones regulating energy balance are of special interest as potential risk factor indicators of cardiovascular diseases.
openaire +3 more sources
The role of ghrelin and ghrelin analogues in wasting disease
Current Opinion in Clinical Nutrition and Metabolic Care, 2008The purpose of this review is to summarize recent studies that investigated the role of ghrelin and ghrelin analogs in wasting conditions.Numerous studies have demonstrated potential beneficial effects exerted by ghrelin in a number of diseases associated with wasting.
Mayra Mayumi Kamiji, Akio Inui
openaire +3 more sources
2013
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R) which was identified in the pituitary gland and is now named the ghrelin receptor. However, the peptide is most abundant in the stomach and ghrelin receptors are present in all major organ systems and tissues.
openaire +2 more sources
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R) which was identified in the pituitary gland and is now named the ghrelin receptor. However, the peptide is most abundant in the stomach and ghrelin receptors are present in all major organ systems and tissues.
openaire +2 more sources