Results 301 to 310 of about 93,938 (325)

From Ghrelin to Ghrelin's O-Acyl Transferase

2012
The hormone ghrelin is a unique signaling peptide with powerful metabolic effects, mediated by its acylated forms. The acyl modification of ghrelin is unique in that it takes place via a susceptible ester linkage in the conserved serine-3 of ghrelin and is composed principally of octanoyl and, to lesser extent, decanoyl fatty acids.
John E. Hale, Richard E. Higgs, Patricia J. Solenberg, Jill A. Willency, Doug R. Perkins, Jesus A. Gutierrez, Tamer Coskun, Michael D. Knierman   +7 more
openaire   +3 more sources

Ghrelin and the Endocrine Pancreas

Endocrine, 2003
Ghrelin is a 28-amino-acid peptide predominantly produced by the stomach, while substantially lower amounts derive from other tissues including the pancreas. It is a natural ligand of the GH secretagogue (GHS) receptor (GHS-R1a) and strongly stimulates GH secretion, but acylation in serine 3 is needed for its activity.
BROGLIO, Fabio, GOTTERO C, BENSO, Andrea Silvio, PRODAM F, VOLANTE, Marco, DESTEFANIS S, GAUNA C, MUCCIOLI, Giampiero, PAPOTTI, Mauro Giulio, VAN DER LELY AJ, GHIGO, Ezio   +10 more
openaire   +6 more sources

Ghrelin

2016
Ghrelin (GHRL) was first discovered as a growth hormone secretagog secreted from the stomach, and showed a novel regulatory pathway for GH secretion. In addition to this, feeding-stimulatory activity is expected from the production site in the arcuate nuclei of the hypothalamus, and it is now recognized as the only hormone to stimulate food intake ...
openaire   +2 more sources

The Structure of Ghrelin

2007
The structure of ghrelin, a 28-residue octanoylated peptide hormone, is only known up to the level of primary structure identifying an active core of residues 1-5 or 1-4 including octanoyl-Ser3 as necessary to elicit receptor response. This chapter reviews the results and limitations of experimental and computer modeling studies, which have appeared in
openaire   +3 more sources

Ghrelin

2009
Ghrelin, öncelikli olarak midedeki endokrin X(A) hücreleri tarafından salgılanan polipeptid yapıda bir hormondur. Ghrelin, büyüme hormonunun salınımı, enerji dengesi, besin alımı ve vücut ağırlığının ayarlanmasında görev alır. 28 aminoasitten oluşan moleküler yapısında, 3.
İLHAN, Tuncay, ERDOST, Hatice
openaire   +2 more sources

Transgenic Mice Overexpressing Ghrelin or Ghrelin Analog

2012
To understand the chronic effects of ghrelin, genetically engineered mouse models would be useful. Early studies, however, suggested that it was challenging to generate ghrelin gain-of-activity models by standard procedures. Although several groups have been trying to generate transgenic (Tg) mice overexpressing ghrelin, almost all these animals ...
Hiroshi Iwakura, Go Yamada, Kazuwa Nakao, Hiroyuki Ariyasu, Kenji Kangawa, Takashi Akamizu, Takashi Akamizu   +6 more
openaire   +3 more sources

Ghrelin and Prostate Cancer

2007
Ghrelin, a 28-amino acid octanoylated peptide predominantly produced by the stomach, has been discovered to be a natural ligand of the type 1a growth hormone secretagogue receptor (GHSR1a). Ghrelin has recently attracted the interest as a new GH-releasing and orexigenic factor.
LANFRANCO, Fabio, BALDI, Matteo Domenico, CASSONI, Paola, BOSCO, MARTINO, GHE', Corrado, MUCCIOLI, Giampiero   +5 more
openaire   +4 more sources

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Nature, 1999
M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, K. Kangawa   +5 more
semanticscholar   +1 more source

Ghrelin induces adiposity in rodents

Nature, 2000
M. Tschöp, D. Smiley, M. Heiman
semanticscholar   +1 more source

Structure and Function of Ghrelin

2008
The endogenous ligand for growth-hormone secretagogue receptor (GHS-R) was purified from the stomach and we named it "ghrelin", after a word root ("ghre") in Proto-Indo-European languages meaning "grow", since ghrelin has potent growth hormone (GH) releasing activity.
Masayasu Kojima, Kenji Kangawa
openaire   +4 more sources