Results 41 to 50 of about 26,677 (229)

Reconstruction of metatarsal bone after giant cell tumor resection with no vascularized fibular graft in a pediatric patient: Case report and review of literature

Frontiers in Pediatrics, 2022
The Giant Cell tumor (GCT) is a benign, locally aggressive lesion that cause bone destruction and shows a malignant potential. It is a relatively common skeletal tumor that is therefore typically seen in young adults.
M. Florio, S. Careri, C. Zoccali, A. G. Aulisa, A. G. Aulisa, F. Falciglia, R. M. Toniolo, M. Giordano   +7 more
doaj   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Significance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review

Diagnostics
Background: Giant cell tumor of bone (GCTB) is a locally aggressive tumor. It accounts for only 5% of all bony tumors. Early diagnosis, and follow-up for recurrence is often difficult due to a lack of biogenetic markers.
Muhammad Taqi, Haseeb ul Rasool, Mobeen Zaka Haider, Munjed Al Muderis   +3 more
doaj   +1 more source

Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy

Advanced Science, EarlyView.
As an inevitable disease, muscle atrophy has received more attention. Because the factors that induce this disease are diverse, achieving a complete cure is still impossible. Wearable bioelectronics provides a more comfortable, low‐cost, and efficient way of home care for the monitoring and treatment of muscle atrophy. Therefore, this review summarizes
Shuai Zhang, Renjie Tan, Shuo Meng, Ke Zhang, Jinlian Hu   +4 more
wiley   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Tumor Auxiliary Prediction Strategy Based on Multiscale Feature Fusion in Medical Decision‐Making System

Advanced Intelligent Systems, EarlyView.
GA: MCFFS method architecture. Pathological images are processed by the multi‐level feature information fusion (MLFF) method and the multi‐scale feature map fusion strategy to achieve the recognition result of cell nuclei. The MLFF module contains convolution blocks, spatial self‐attention, and atrous spatial pyramid pooling.
Yingqing Lu, Jing Zhou, Fangfang Gou, Jia Wu   +3 more
wiley   +1 more source

Giant-Cell Tumor of the Distal Ulna Treated by Wide Resection and Ulnar Support Reconstruction: A Case Report

Case Reports in Medicine, 2010
Giant-cell tumor of bone occurred in the distal end of the ulna is extremely uncommon. A 23-year-old male had a giant-cell tumor occurred in the distal end of the ulna.
Akio Minami, Norimasa Iwasaki, Kinya Nishida, Makoto Motomiya, Katsuhisa Yamada, Daisuke Momma   +5 more
doaj   +1 more source

Do we need internal fixation devices for giant cell tumors around knee joint? An outcome study

Journal of Orthopaedic Diseases and Traumatology, 2018
Introduction: Giant cell tumors around the knee joint are the most common aggressive benign tumors. Several limb sparing and limb ablation surgeries are practiced with varying level of success.
Ritesh Runu, Vidya Sagar, Ashutosh Kumar, Arnab Sinha, Santosh Kumar   +4 more
doaj   +1 more source

Segmentation of cortical bone, trabecular bone, and medullary pores from micro‐CT images using 2D and 3D deep learning models

The Anatomical Record, EarlyView.
Abstract Computed tomography (CT) enables rapid imaging of large‐scale studies of bone, but those datasets typically require manual segmentation, which is time‐consuming and prone to error. Convolutional neural networks (CNNs) offer an automated solution, achieving superior performance on image data.
Andrew H. Lee, Julian M. Moore, Brandon Vera Covarrubias, Leigha M. Lynch   +3 more
wiley   +1 more source

Histological Regression of Giant Cell Tumor of Bone Following RANK Ligand Inhibition

Journal of Investigative Medicine High Impact Case Reports, 2014
Lung metastases are a rare complication of giant cell tumors of bone. We herein describe an interesting case of histological regression and size reduction of lung metastases originating from a primary giant cell tumor of bone in response to the RANK ...
Martin F. Dietrich MD, PhD, Dominick Cavuoti MD, Michael Landay MD, Yull E. Arriaga MD   +3 more
doaj   +1 more source