Results 81 to 90 of about 62,350 (252)

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel. [PDF]

, 2019
Pexidartinib (PLX3397) is a small molecule tyrosine kinase and colony-stimulating factor-1 inhibitor with FDA breakthrough therapy designation for tenosynovial giant-cell tumor, and currently under study in several other tumor types, including breast ...
Chien, A Jo, Esserman, Laura J, Hyland, Colby, Piawah, Sorbarikor, Rugo, Hope S, Umetsu, Sarah E   +5 more
core  

Recurrent temporal bone tenosynovial giant cell tumor with chondroid metaplasia: the use of imaging to assess recurrence [PDF]

, 2014
Tenosynovial giant cell tumor (TGCT) is a benign proliferative lesion of unclear etiology. It is predominantly monoarticular and involves the synovium of the joint, tendon sheath, and bursa.
Fernandez, M., Garcia, R., Maya, S., Noor, A., Pawha, P., Pina, S., Som, P.   +6 more
core   +1 more source

Vascular Reconstruction in Extremity Soft Tissue Sarcomas: A Systematic Review and Single‐Arm Meta‐Analysis

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction The management of extremity soft tissue sarcomas (STS) involving major vessels presents unique challenges, historically leading to amputation. Advances in vascular reconstruction have enabled limb‐sparing surgery (LSS), but outcomes and perioperative risks remain uncertain.
Lucas Monteiro Delgado, Bernardo Fontel Pompeu, Vinícius dos Santos Macedo, Gabriel Henrique Acedo Martins, Eric Pasqualotto, Matheus Reginato Araujo, Julia Hoici Brunini, Victor Andrade Nunes, Cláudia Theis, Samuel Aguiar Junior   +9 more
wiley   +1 more source

Giant cell tumor of the bone with fatal pulmonary metastasis: A case report

SAGE Open Medical Case Reports
Giant cell tumors of the bone are typically benign, locally aggressive lesions that rarely metastasize. In this report, we describe the case of a 48-year-old woman presenting with a giant cell tumor of the bone of the hip joint, which demonstrated ...
Mohamad Taha, Saadia A. Faiz, Pushan Jani, Jing Liu, Yasir D. Ali, Mohammad Asim Amjad   +5 more
doaj   +1 more source

Wide Resection and Iliac Crest Arthrodesis for Multiply Recurrent Giant Cell Tumor of First Metatarsal

Case Reports in Orthopedics, 2018
Case. Giant cell tumor of bone is a benign, aggressive neoplasm commonly arising in the femur, tibia, and distal radius and less commonly in the hands and feet.
Andrew Golz, Michael Murphy, Lukas Nystrom, Adam Schiff   +3 more
doaj   +1 more source

Patellar Giant-Cell Tumor: a Case Report

Journal of Experimental Life Science, 2018
Giant cell tumor (GCT) found mostly in the long bones metaphysis or epiphysis. GCT usually occur between the ages of a third and fourth decade and locally aggressive. Giant-Cell Tumor seldom affects the patella. Multicentric forms rarely reported.
Istan Irmansyah Irsan, Satria Pandu Persada, Rakhmad Aditya   +2 more
doaj   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Dedifferentiated giant-cell tumor of bone with an undifferentiated round cell mesenchymal component

Rare Tumors, 2014
The dedifferentiated giant-cell tumor of the bone is a very rare variant of the giant-cell tumor (GCT). We report the clinical, radiographic and histological findings of a dedifferentiated GCT in which the dedifferentiated component consisted of small ...
Eréndira G. Estrada-Villaseñor, Socorro Cortés-González, Luis Miguel Linares-González, Roberto González-Guzmán, Genaro Rico-Martínez   +4 more
doaj   +1 more source

Giant Cell Tumor with Aneurysmal Bone Cyst Changes of Proximal Fibula in a Young Male - A Case Report

Journal of Clinical and Biomedical Sciences, 2020
Giant cell tumor (GCT) account around 5% of bone tumors with a slight female preponderance. We are presenting a case 32yr old gentleman, who presented with c/o swelling present on lateral aspect of proximal third of left leg for past one year ...
Sakthikesavan sivanandan, Hariprasad seenappa, Satyarup Dassanna, Varsha Shree R   +3 more
doaj   +1 more source

Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell‐of‐origin model for osteoid osteoma and osteoblastoma

The Journal of Pathology, EarlyView.
Abstract Osteoid osteoma and osteoblastoma are non‐malignant bone‐forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in osteoid osteoma and osteoblastoma.
Suk Wai Lam, Tatiana Belova, Natasja Franceschini, Brendy van den Akker, David GP van IJzendoorn, Harald MM Mikkers, Hailiang Mei, Anne‐Marie Cleton‐Jansen, Marieke L Kuijjer, Karoly Szuhai, Judith VMG Bovée   +10 more
wiley   +1 more source