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Giant cell arteritis: Its ophthalmic manifestations
Giant cell arteritis (GCA) is the most important medical emergency in ophthalmology, because its most dreaded complication is visual loss, which is preventable if these patients are diagnosed early and treated immediately and aggressively.
S. Hayreh
semanticscholar +1 more source
Macrophages mediate inflammation, angiogenesis, and tissue destruction in giant cell arteritis (GCA). Serum levels of the macrophage‐associated protein YKL‐40 (chitinase 3–like protein 1), previously linked to angiogenesis and tissue remodeling, remain ...
Y. van Sleen+8 more
semanticscholar +1 more source
Clinical Features of Aortitis with Gastrointestinal Involvement
Few vascultides have a predilection for the aorta. Among those are Takayasu arteritis, Behcet’s disease, giant cell arteritis, and infectious aortitis.
Mansour Altuwaijri, Abdulmajeed Altoijry
doaj +1 more source
Giant cell arteritis is a granulomatous vasculitis of large and medium sized arteries manifesting as temporal arteritis and/or polymyalgia rheumatica.
Salem Alowami+3 more
doaj +1 more source
A meta-analysis of the epidemiology of giant cell arteritis across time and space
Introduction Giant cell arteritis (GCA) is a common large vessel vasculitis in those over age 50 years. This meta-analysis examined the geographical and temporal distribution of the incidence, prevalence, and mortality of GCA. Methods A systematic review
Katherine Li+3 more
semanticscholar +1 more source
Pathogenesis of polymyalgia rheumatica [PDF]
Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis.
Ciccia F.+4 more
core +1 more source
Treatment failure in giant cell arteritis
Objective Identify predictors of treatment failure in patients with giant cell arteritis (GCA) receiving tocilizumab in combination with glucocorticoids and in patients with GCA receiving only glucocorticoids.
S. Unizony+5 more
semanticscholar +1 more source
Temporal arteritis, a chronic inflammatory vasculitis involving medium- and large-sized arteries, has rarely been reported in Asia. However, we report 2 cases, in which the patients initially presented with headache.
Chen, Chun-Hsiung+5 more
core +2 more sources
Disease stratification in giant cell arteritis to reduce relapses and prevent long-term vascular damage [PDF]
For years, clinicians and researchers working on giant cell arteritis have been battling with the conundrum of a disease that displays a short-term steroid responsiveness but is burdened by a remarkable risk of flares and chronic damage in the long term.
Dasgupta, Bhaskar+6 more
core +1 more source
Model of inverse bleb growth explains giant vacuole dynamics during cell mechanoadaptation [PDF]
Cells can withstand hostile environmental conditions manifest as large mechanical forces such as pressure gradients and/or shear stresses by dynamically changing their shape. Such conditions are realized in the Schlemm's canal of the eye where endothelial cells that cover the inner vessel wall are subjected to the hydrodynamic pressure gradients ...
arxiv +1 more source