Results 71 to 80 of about 5,817,209 (301)

Usefulness of immunosuppression for giant cell myocarditis [PDF]

, 2008
Giant cell myocarditis (GCM) is a rare and highly lethal disorder. The only multicenter case series with treatment data lacked cardiac function assessments and had a retrospective design. We conducted a prospective, multicenter study of immunosuppression
Giant Cell Myocarditis Treatment Trial Investigators, Deng MC, Cunningham MW, Cooper LT Jr, Starling RC, Jaski B, Bailey KR, Dec GW, Caforio A, Hare JM, Menon S, Edwards WD, Mullen GM, Tazelaar HD   +13 more
core   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Giant Cell Tumor of Bone: An Update.

, 2021
PURPOSE OF REVIEW: To highlight the new developments in the management of advanced giant cell tumor of bone, a rare locally aggressive benign tumor, which was traditionally managed with surgery alone by either curettage and local adjuvant therapy, wide ...
Basu Mallick, Atrayee, Chawla, Sant P
core   +1 more source

FDG uptake in giant cell tumor of the tendon sheath in a patient restaged for gastrointestinal stroma tumor (GIST)

, 2009
A 70-year-old man known for recurrent abdominal gastrointestinal stroma tumor presented with a suspicious peritoneal mass demonstrated by an abdominal CT scan.
Siebenrock, KA, Krause, TM, Wissmeyer, M, Stauffer, E, Kohl, S, Juengling, FD   +5 more
core   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Giant-cell tumor of bone: treatment options and role of denosumab

, 2015
Arun S Singh,1 Neal S Chawla,2 Sant P Chawla2 1Sarcoma Service, Division of Hematology/Oncology, University of California, Los Angeles, 2Sarcoma Oncology Center, Santa Monica, CA, USA Abstract: Giant-cell tumor of bone is a rare, locally aggressive ...
Chawla SP, Singh AS, Chawla NS
core  

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

Giant Cell Tumor of Rib Arising Anteriorly as a Large Inframammary Mass: A Case Report and Review of the Literature

Case Reports in Medicine, 2012
Introduction. Giant cell tumor of the bone is a rare benign lesion that infrequently affects the ribs, and if present, is usually located posteriorly. The rarity of this tumor poses diagnostic and therapeutic problems for physicians, especially when it ...
Amit Sharma, Amy E. Armstrong
doaj   +1 more source

Fibroma and giant-cell tumor of tendon sheath: a case report

, 2014
Kátia Tôrres Batista,1 Heveline Becker de Moura,1 Maria Isabel Lima,2 Kikue Terada Abe3 1Department of Plastic Surgery and Pathology, 2Electron Microscopy Laboratory, 3Cytogenetic Laboratory, Sarah Hospital Brasilia, Brazil Abstract: A 53 ...
de Moura HB, Lima MI, Abe KT, Batista KT
core  

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source