Results 141 to 150 of about 87,402 (312)

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe   +6 more
wiley   +1 more source

Tenosynovial Giant Cell Tumors in the Hand and Foot. [PDF]

open access: yesCureus
Stefanou N   +5 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes   +7 more
wiley   +1 more source

Expanding the molecular spectrum of tenosynovial giant cell tumors. [PDF]

open access: yesFront Oncol, 2022
Gauduchon T   +12 more
europepmc   +1 more source

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

open access: yesCancer Science, EarlyView.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota   +8 more
wiley   +1 more source

Optimizing Functional Recovery in Multi-Site Giant Cell Tumors. [PDF]

open access: yesJ Orthop Case Rep
Dubey V   +3 more
europepmc   +1 more source

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