Results 141 to 150 of about 30,224 (246)

Giant cell tumour of bone around the knee: a systematic review of the functional and oncological outcomes. [PDF]

open access: yesEFORT Open Rev, 2021
Soares do Brito J   +4 more
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo   +8 more
wiley   +1 more source

Surgical challenges, novel techniques, and systemic treatment of giant cell tumour of bone of the distal radius : clinical outcomes and systematic review of the literature. [PDF]

open access: yesBone Jt Open, 2022
van der Heijden L   +6 more
europepmc   +1 more source

When an Oral Lesion Uncovers Hyperparathyroidism: A Peripheral Brown Tumor Case

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Oral lesions may represent the first sign of an underlying systemic disease. Giant cell lesions in the oral cavity should prompt investigation for hyperparathyroidism, as early recognition of brown tumors allows appropriate systemic management and may lead to lesion regression after treatment of the endocrine disorder.
Bruno Teixeira Gonçalves Rodrigues   +6 more
wiley   +1 more source

Hydatid Cyst of the Thyroid Gland With Concurrent Hepatic Involvement: A Rare Case Report

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Hydatidosis, caused by Echinococcus granulosus, most commonly affects the liver and lungs, while thyroid involvement is exceptionally rare and can mimic other cystic thyroid lesions. We report a 40‐year‐old woman with no history of animal exposure who presented with anterior neck swelling, odynophagia, and abdominal discomfort. She had a prior
Hana Saffar, Aysan Nozheh, Maral Edalati
wiley   +1 more source

Bone: Giant cell tumour [PDF]

open access: yesAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
RG Forsyth, PCW Hogendoorn
openaire   +1 more source

Surgical Resection of Lumbar Spine Osteoblastoma With Secondary Aneurysmal Bone Cysts Through a Combined Transpsoas and Posterior Approach: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Aggressive lumbar osteoblastoma with secondary aneurysmal bone cysts is rare and may involve both posterior elements and vertebral bodies. When extensive multilevel involvement is present, a combined posterior and transpsoas approach can facilitate complete tumor resection, restore spinal stability, and achieve favorable neurological and ...
Enliang Chen   +8 more
wiley   +1 more source

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma

open access: yesJournal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh   +4 more
wiley   +1 more source

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