Results 141 to 150 of about 152,261 (253)

Making a giant: Uncovering gene regulation underlying the formation of giant cells in Arabidopsis sepals. [PDF]

Plant Cell, 2023
Herrera-Ubaldo H.
europepmc   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures. [PDF]

PLoS Biol
Converse A, Perry MJ, Dipali SS, Isola JVV, Kelly EB, Varberg JM, Zelinski MB, Stout MB, Pritchard MT, Duncan FE.   +9 more
europepmc   +1 more source

Circulating cancer giant cells with unique characteristics frequently found in patients with myelodysplastic syndromes (MDS). [PDF]

Med Oncol, 2023
Ali AM, BenMohamed F, Decina A, Mukherjee S, Levi S, Garrido Castillo LN, Bréchot D, Jurcic J, Raza A, Paterlini Bréchot P.   +9 more
europepmc   +1 more source

Emerging Device Applications From Strong Light–Matter Interactions in 2D Materials

Advanced Science, EarlyView.
Two‐dimensional semiconductors enable extremely compact optoelectronic devices such as solar cells, sensors, LEDs, and lasers. Their strong light–matter interactions allow efficient light emission, detection, and energy conversion. This review article discusses the recent progress in integrating these materials with optical cavities and nanostructures ...
Janani Archana K, Kumar Shwetabh, Reyas Ali, Ramji Velayutham, Koustav Das, Abhishek Mondal, Prashant Kumar, Surendra B. Anantharaman   +7 more
wiley   +1 more source

Feline uterine carcinosarcoma infiltrated with osteoclast-like giant cells. [PDF]

J Vet Med Sci, 2022
Murakami M, Yonemaru K, Goto M, Owaki K, Hirata A, Kunihiro S, Sakai H.   +6 more
europepmc   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Characterization of undifferentiated carcinomas of the pancreas with and without osteoclast-like giant cells. [PDF]

JNCI Cancer Spectr
Mills JN, Gunchick V, McGue J, Qin Z, Kumar-Sinha C, Bednar F, Brown N, Shi J, Udager AM, Frankel T, Zalupski MM, Sahai V.   +11 more
europepmc   +1 more source

Orientation‐Confinement‐Engineered Stabilization of Ferroelectricity in HfO2 toward Maximum Polarization

Advanced Science, EarlyView.
Ferroelectric phase stability in Hf₀.5Zr₀.5O2 films is enhanced by confinement to the (111) crystal orientation, as demonstrated by first‐principles calculations and experiments. Polarization approaching its maximum value is achieved through selective ferroelectric switching paths, which are further tuned by oxygen vacancies and cation doping to ...
Fatoye Sawyerr, Yongqing Sun, Zekun Zhang, Kang Jia, Shuning Lv, Qi Hu, Shu Shi, Qiushi Huang, Xie Zhang, Xiaoli Fan, Li‐min Liu, Shifeng Wen, Zheng Wen, Tengfei Cao, Jingsheng Chen   +14 more
wiley   +1 more source

A current knowledge of the undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: a narrative review. [PDF]

J Gastrointest Oncol
Gayibov E, Sychra T, Souček P, Oliverius M.   +3 more
europepmc   +1 more source