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Unusual clinical presentations of giant prolactinomas

Pituitary, 2008
Giant prolactinomas are rare pituitary tumors which have scarcely been reported in the literature. We describe three men with unusual presenting features of prolactin-secreting giant pituitary adenomas: prolonged and increasingly disturbing intolerance to light and noise; strange behavior and mood disturbances; and rhinorrhea followed by a finding of ...
Simona, Grozinsky-Glasberg, Ilan, Shimon
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Giant Prolactinoma and Effectiveness of Medical Management

Endocrine Practice, 2010
To review our experience with long-term cabergoline and bromocriptine therapy in the treatment of giant prolactinomas.Patients with giant prolactinomas diagnosed and treated at our center in Mumbai, India, between January 2005 and January 2009 were included.
Shrikrishna V, Acharya   +4 more
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A GIANT PROLACTINOMA: A CASE REPORT

PARIPEX INDIAN JOURNAL OF RESEARCH, 2022
A 38-years-old woman presented to our hospital 2 years ago with 5-year history of reduced vision, chronic cephaleea and secondary amenorrhea. Her baseline prolactin level was 46504 µIU/mL (reference range=127-637mUI/ml) with secondary hypogonadism, and pituitary magnetic resonance imaging revealed a giant prolactinoma (4 × 2.2 × 2.6 cm3) with ...
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Giant prolactinoma and hook effect

Neurology, 2000
A 27-year-old man presented with headache, bitemporal hemianopia, memory deficit, gait disturbance, and impotence. MRI revealed a giant pituitary tumor (figure). Serum prolactin level was initially reported as 78 ng/mL. The slightly elevated prolactin was falsely attributed to stalk effect. The patient was scheduled for surgery.
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Giant prolactinomas presenting as skull base tumors

Surgical Neurology, 2002
Prolactinomas invading the skull base are rare, and could easily be confused with skull base tumors of nonpituitary origin.We report a series of 4 cases of giant prolactinomas invading the skull base and presenting with atypical symptoms. Case 1 presented with a short history of headache and nasal obstruction.
MINNITI, GIUSEPPE   +6 more
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[Invasive giant prolactinoma].

Acta otorrinolaringologica espanola, 1998
Large prolactin-secreting tumors are rare and their endocrinological and surgical management may be complex. We report the case of a patient with a prolonged history of unilateral tinnitus and sensation of a stopped-up ear who had a very large, invasive and aggressive tumor of the sphenoidal region with bone destruction, invasion of structures in every
L J, Domínguez Ugidos   +5 more
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Giant basal prolactinoma extending into the nasal cavity

Surgical Neurology, 1992
An unusual case of a giant prolactinoma extending to the nasopharynx and nasal cavity is presented. A 35-year-old man admitted for nasal obstruction and visual disturbances was found to have bilateral anosmia, right homonymous hemianopsia, and a right hemiparesis. The serum prolactin level was 13,300 ng/mL.
Y, Iwai   +6 more
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Giant prolactinomas in men: efficacy of cabergoline treatment

Clinical Endocrinology, 2003
Summaryobjective The term ‘giant prolactinoma’ can be used for tumours larger than 4 cm in diameter and/or with massive extrasellar extension. Cabergoline (CAB), a long‐lasting dopamine agonist (DA), safe and well tolerated, is effective in normalizing PRL levels and inducing tumour shrinkage in micro‐ and macroprolactinomas.
Corsello, Salvatore Maria   +6 more
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Giant prolactinomas in adolescence: an uncommon cause of blindness

Child's Nervous System, 2006
Prolactinomas in childhood and adolescence are rare. However, in male patients in particular they may become extremely large and invasive, resulting in visual impairment without necessarily producing endocrine symptoms.We report on two adolescent males who presented with deteriorating vision over a long period of time and who had optic atrophy on ...
Patrick, Semple   +3 more
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Nephrotic-Range Proteinuria in a Patient With a Giant Prolactinoma

American Journal of Kidney Diseases, 2008
We report for the first time a case of nephrotic-range proteinuria adequately controlled by using dopamine agonists. A 40-year-old man was studied because of persistent asymptomatic nephrotic proteinuria despite lifestyle modifications and treatment with converting enzyme inhibitors. The renal biopsy specimen did not show histopathologic changes.
Manuel, Heras   +7 more
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