Results 51 to 60 of about 1,136,132 (301)
Negotiating textual talk : conversation analysis, pedagogy, and the organisation of online asynchronous discourse [PDF]
, 2009 This paper uses Conversation Analysis to investigate the ways in which participants in an online asynchronous postgraduate reading group managed and negotiated their contributions within the discussion.
Gibson, William
core +2 more sources
Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer
Advanced Science, EarlyView.The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang +10 more
wiley +1 more source
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
The History and Philosophy of Ecological Psychology
Frontiers in Psychology, 2018 Ecological Psychology is an embodied, situated, and non-representational approach pioneered by J. J. Gibson and E. J. Gibson. This theory aims to offer a third way beyond cognitivism and behaviorism for understanding cognition.
Lorena Lobo +2 more
doaj +1 more source
We don’t need just the DFC, we needs lots of comics, and what’s more, we can make them. Let’s get to it! [PDF]
, 2010 Comics have too often been dismissed as unsophisticated, popular culture texts or as a phase of reading which children are encouraged to move out of towards more ‘worthy’ literary fare.
Gibson, Mel
core
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Optimizing Genetic Manipulation of Methanogens through Faster Cloning Techniques [PDF]
, 2018 Methanogenesis is the biological production of methane. Only anaerobic archaea known as methanogens are capable of such a metabolic feat. They have strict living conditions and substrate sources which determine their rate of metabolism.
Jennings, Merrisa
core +2 more sources
On the Stability of Thermonuclear Burning Fronts in Type Ia Supernovae
, 2004 The propagation of cellularly stabilized thermonuclear flames is investigated by means of numerical simulations. In Type Ia supernova explosions the corresponding burning regime establishes at scales below the Gibson length.
A.R. Kerstein +12 more
core +2 more sources
Advanced Science, EarlyView.A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son +2 more
wiley +1 more source
On the Reduction of Radiation Damping of Dynamic Foundation on Gibson Elastic Halfspace
Shock and VibrationFor dynamic machine foundations, it is widely acknowledged that the radiation damping ratio estimated by Lysmer’s analogy method is often overestimated, leading to the adoption of modifications in design codes across various nations.
Hao Li, Xiaohui Cheng
doaj +1 more source