Results 81 to 90 of about 766,392 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Advancement, Fall 1998 [PDF]

open access: yes, 1998
Advancement, a supplement to Bostonia magazine, provided updates on BU development activities, including major gifts and ...
Boston University Office of Development and Alumni Relations
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Mărturii cu valoare artistică ale culturii urbane din Banat în epoca modernă în colecțiile Muzeului Național al Banatului.

open access: yesAnalele Banatului. Arheologie-Istorie, 2020
This article illustrates the exhibitions and the strategy to enrich the cultural heritage of the National Museum of Banat through acquisitions and gifts during the years 2019–2020, when a large number of objects were registered in the inventories of the ...
Marius Cornea
doaj  

Instituția căsătoriei și statutul femeii în legislația medievală a secolului al XVII-lea [PDF]

open access: yesDialogica: Revistă de Studii Culturale și Literatură
The matrimonial institution in the 17th century, more precisely its legal definition, determines the status of women. In a century in which the sources reflect a predominantly male world, the girl has no other alternative than marriage or the convent ...
Elena GHEORGHE
doaj   +1 more source

Gifts that recalibrate relationships: marriage prestations in an Arab liberation movement [PDF]

open access: yes, 2018
Enduring scholarly interest in the social relations of gift exchange has, following Mauss, emphasised how gifts make relationships. Where gifts break relationships, their ethnographic distinctiveness has reinforced the wider notion that gifts are good at
Wilson, Alice
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Rules of Engagement [PDF]

open access: yes, 1998
Why does the law treat engagement rings differently from other gifts? The answer is rooted in a history in which courts generally entertained litigation over broken engagements.
Tushnet, Rebecca
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

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