Results 101 to 110 of about 7,162,114 (343)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng   +4 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

open access: yesAdvanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha   +2 more
wiley   +1 more source

气体绝缘金属封闭输电线路雷电侵入过电压研究

open access: yesDianci bileiqi, 2018
气体绝缘金属封闭输电线(GIL)因其具有容量大、传输损耗少等优点逐步得到推广,需要分析GIL雷电过电压威胁及其相应防护措施。利用EMTP软件搭建500 k V输电线路和GIL模型,计算线路发生反击和绕击情况下GIL雷电过电压,比较过电压暂态特性差异,分析过电压对绝缘威胁及安装额外金属氧化物避雷器对过电压的抑制效果,讨论GIL上避雷器安装位置对防护效果的影响。分析结果表明:线路发生反击时,GIL过电压波形振荡比绕击时剧烈,但过电压幅值要低于绕击情况。距离雷击点越远,GIL过电压幅值越高 ...
韦成杰, 马蕾
doaj  

Análises Linguísticas: textos em diferentes perspectivas de estudo - doi: 10.4025/actascilangcult.v32i2.10031

open access: yesActa Scientiarum: Language and Culture, 2010
CARDOSO, Beatriz Daruj; GIL, Elis de Almeida; GONDÉ, Valéria Gil. Modelos de análise linguística. São Paulo: Contexto, 2009.
Elaine de Moraes Santos   +1 more
doaj   +1 more source

Boston University Wind Ensemble, December 6, 2001 [PDF]

open access: yes, 2001
This is the concert program of the Boston University Wind Ensemble performance on Thursday, December 6, 2001 at 8:00 p.m., at the Tsai Performance Center, 685 Commonwealth Avenue. Works performed were "Geschwindmarsch" by Beethoven.
School of Music, Boston University
core  

Data‐Driven Review and Machine Learning Prediction of Diamond Vacancy Center Synthesis

open access: yesAdvanced Intelligent Systems, EarlyView.
A machine learning framework is applied to photoluminescence spectra to extract linewidths and uncover how NV, SiV, GeV, and SnV centers evolve with growth and processing conditions. Unified normalization and k‐fold validation reveal cross‐method trends and enable rapid prediction of defect size and fabrication parameters, offering a data‐driven route ...
Zhi Jiang   +3 more
wiley   +1 more source

Research progress on metal particle contamination in GIS/GIL

open access: yesCSEE Journal of Power and Energy Systems, 2019
The metal particle contamination in gas-insulated switchgear (GIS) or gas-insulated transmission line (GIL) is an important factor leading to the decline of insulation performance.
Jian Wang   +7 more
semanticscholar   +1 more source

Pathogenic PF4/Polyanion ELISA‐Negative Antibodies in HIT

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Background Platelet factor 4‐polyanion enzyme‐linked immunosorbent assays (ELISAs) are considered highly sensitive for diagnosing heparin‐induced thrombocytopenia (HIT), such that current practice guidelines recommend use of ELISA‐negative results to exclude HIT.
Adam J. Kanack   +25 more
wiley   +1 more source

Real‐World Outcomes of FLAG‐Ida Regimen in 1079 Adult Patients With First Relapsed/Refractory AML: A PETHEMA Study

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT In a large multicenter real‐world cohort, we aimed to evaluate outcomes of FLAG‐Ida salvage therapy for relapsed/refractory (R/R) acute myeloid leukemia (AML) and validated the SALFLAGE prognostic score. We analyzed 1079 adults with R/R AML treated across 112 PETHEMA institutions over 26 years (1998–2024), including patients with primary ...
Gaspar Aspas Requena   +49 more
wiley   +1 more source

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