Results 1 to 10 of about 962,583 (347)

Behavioral and Transcriptomic Changes Following Brain-Specific Loss of Noradrenergic Transmission

Biomolecules, 2023
Noradrenaline (NE) plays an integral role in shaping behavioral outcomes including anxiety/depression, fear, learning and memory, attention and shifting behavior, sleep-wake state, pain, and addiction.
Elsa Isingrini, Chloé Guinaudie, Léa Perret, Elisa Guma, Victor Gorgievski, Ian D. Blum, Jessica Colby-Milley, Maryia Bairachnaya, Sébastien Mella, Antoine Adamantidis, Kai-Florian Storch, Bruno Giros   +11 more
doaj   +1 more source

Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation

Scientific Reports, 2022
Genetic variants that regulate lipid phosphate phosphatase 3 (LPP3) expression are risk factors for the development of atherosclerotic cardiovascular disease.
Patrick M. Van Hoose, Liping Yang, Maria Kraemer, Margo Ubele, Andrew J. Morris, Susan S. Smyth   +5 more
doaj   +1 more source

Cannabinoid CB1 receptors regulate salivation

Scientific Reports, 2022
Saliva serves multiple important functions within the body that we typically take for granted, such as helping prepare food for swallowing and defense against oral pathogens.
Kelsey Andreis, Jenna Billingsley, Kian Naimi Shirazi, Jim Wager-Miller, Clare Johnson, Heather Bradshaw, Alex Straiker   +6 more
doaj   +1 more source

Microbial Imbalance and Stochastic Assembly Drive Gut Dysbiosis in White-Gill Diseased <i>Larimichthys crocea</i> (Richardson, 1846). [PDF]

Microorganisms
Wang X, Cheng H, Liu T, Wang X, Wu X, Yu J, Zhang D, Shen W, Hou D.   +8 more
europepmc   +3 more sources

Optimizing Antibody Affinity and Developability Using a Framework–CDR Shuffling Approach—Application to an Anti-SARS-CoV-2 Antibody

Viruses, 2022
The computational methods used for engineering antibodies for clinical development have undergone a transformation from three-dimensional structure-guided approaches to artificial-intelligence- and machine-learning-based approaches that leverage the ...
Ranjani Gopal, Emmett Fitzpatrick, Niharika Pentakota, Akila Jayaraman, Kannan Tharakaraman, Ishan Capila   +5 more
doaj   +1 more source

Requiem for Rimonabant: Therapeutic Potential for Cannabinoid CB₁ Receptor Antagonists after the Fall

Drugs and Drug Candidates, 2023
The endocannabinoid system is found throughout the CNS and the body where it impacts many important physiological processes. Expectations were high that targeting cannabinoid receptors would prove therapeutically beneficial; pharmaceutical companies ...
Taryn Bosquez-Berger, Gergő Szanda, Alex Straiker   +2 more
doaj   +1 more source

Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

Molecular Neurodegeneration, 2023
Human studies consistently identify bioenergetic maladaptations in brains upon aging and neurodegenerative disorders of aging (NDAs), such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis.
Sen Yang, Jung Hyun Park, Hui-Chen Lu
doaj   +1 more source

Thickness variation in contoured composite parts by vacuum infusion

Advanced Manufacturing: Polymer & Composites Science, 2023
Contoured laminates were produced by vacuum infusion (VI), and thickness variations were monitored dynamically as a function of process parameters. Process simulations were performed using finite element software (PAM-RTM), and predictions of thickness ...
Patricio Martinez, Bo Jin, Steven Nutt
doaj   +1 more source

Permeability of co-cured honeycomb sandwich skins: effect of gas transport during processing

Advanced Manufacturing: Polymer & Composites Science, 2020
Potential links between pressure conditions during co-cure of honeycomb sandwich panels, the extent of gas flow through facesheet and bond-line, and the level of permeability in the cured skin were evaluated.
Trisha Palit, Timotei Centea, Mark Anders, Daniel Zebrine, Steven Nutt   +4 more
doaj   +1 more source

Surface porosity development in tool-side facesheets of honeycomb core sandwich structures during co-cure

Advanced Manufacturing: Polymer & Composites Science, 2022
Co-cure of honeycomb core sandwich structures combines the consolidation of composite prepreg facesheets with bonding of facesheets to a low-density core in a single thermal cycle for efficient manufacturing.
Daniel Zebrine, Elana Wadhwani, Steven Nutt   +2 more
doaj   +1 more source