Results 31 to 40 of about 5,669 (231)

Nifedipine-induced gingival enlargement: Correlation with dose and oral hygiene

Journal of Pharmacy and Bioallied Sciences, 2012
Gingival enlargement is a common finding in a routine dental practice. Though it has many etiological factors, enlargement due to drugs which are administered to treat the systemic problems is of major concern which needs attention.
Paramel Mohan Sunil, Jai Sanghar Nalluswami, Suman Jai Sanghar, Issac Joseph   +3 more
doaj   +1 more source

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

Prevalence of Amlodipine-induced gingival enlargement in a Tertiary Care Hospital: A Descriptive Cross-Sectional Study

Journal of Nepal Medical Association
Introduction: Administration of certain drugs such as anticonvulsants, immunosuppressants, and calcium channel blockers leads to well-known sequalae of gingival enlargement. Apart from esthetic consequences, gingival enlargement also hinders proper oral
Gitanjali Subedi, Arjun Hari Rijal, Simant Lamichhane, Osha Ghimire, Manoj Humagain   +4 more
doaj   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Severe drug-induced gingival enlargement and periodontitis: A case series with clinical presentation and management

Oral and Maxillofacial Surgery Cases, 2020
Gingival enlargement (GE) is a condition in which the size of the gingiva increases in response to inflammation, systemic disease, or certain medications including anticonvulsants, calcium-channel blockers, and immunosuppressants.
Janina Golob Deeb, Denver J. Lyons, Daniel M. Laskin, George R. Deeb   +3 more
doaj   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

A Rare Case Report of Amlodipine-Induced Gingival Enlargement and Review of Its Pathogenesis

Case Reports in Dentistry, 2013
Gingival enlargement is a common clinical feature of gingival and periodontal diseases. It is an unwanted side effect of certain systemic drugs given for nondental treatment.
Sanjeev Joshi, Sucheta Bansal
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

High‐Performance Ambipolar Organic Electrochemical Transistors Based on Diketopyrrolopyrrole‐Dialkoxybithiazole Conjugated Polymers for Single‐component Inverters

Advanced Science, EarlyView.
Two donor‐acceptor conjugated polymers, incorporating diketopyrrolopyrrole (DPP) and dialkoxybithiazole (2Tz) units with ethylene glycol (EG) side chains, exhibit relatively balanced ambipolar organic electrochemical transistor (OECT) performance. This ambipolarity enables the realization of single‐component complementary inverters capable of ternary ...
Jiazheng Li, Zhi Li, Jiayu Huang, Jingjing Su, Peijie Xu, Siwen Wang, Ping Zhang, Yuchuan Tian, Tao Pan, Junyang Liu, Junyu Li, Gang Ye, Ryan C. Chiechi, Yanxi Zhang, Wenjing Hong   +14 more
wiley   +1 more source