Results 131 to 140 of about 22,019 (240)

Novel therapeutic strategy targeting STMN1 using chlorambucil‐conjugated pyrrole–imidazole polyamide in small cell lung cancer

International Journal of Cancer, Volume 158, Issue 5, Page 1336-1347, 1 March 2026.
What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa, Takayoshi Watanabe, Yoichi Ohtaki, Toshikazu Bando, Hiroshi Sugiyama, Takuya Araki, Hideaki Yashima, Bilguun Erkhem‐Ochir, Haruka Okami, Gendensuren Dorjkhorloo, Ikuma Shioi, Toshiteru Nagashima, Natsuko Kawatani, Tomohiro Yazawa, Eiji Narusawa, Takayuki Kosaka, Osamu Kawashima, Mitsuhiro Kamiyoshihara, John D. Minna, Luc Girard, Ken Shirabe, Hiroki Nagase, Kimihiro Shimizu, Takehiko Yokobori   +23 more
wiley   +1 more source

Establishing a Model for Serious Science Game Design for Elementary Learners: A Longitudinal, Mixed Methods Study of Serious Game Design Mechanics That Facilitate Science Learning

Science Education, Volume 110, Issue 2, Page 501-524, March 2026.
ABSTRACT Immersive learning environments, such as serious educational games (SEGs), offer promising opportunities for enhancing elementary students' science learning outcomes and fostering their interest in science. These environments allow learners to explore scientific phenomena in ways traditional instruction cannot replicate.
Georgia W. Hodges, Kayla Flanagan
wiley   +1 more source

Copy Number Variant Duplications Associated with Essential Tremor. [PDF]

Tremor Other Hyperkinet Mov (N Y)
Medeiros M, Liao C, Dilliott AA, Ross JP, Vuokila V, Aboasali F, Castonguay CE, Spiegelman D, Hopfner F, Vilariño-Güell C, García-Martín E, Alonso-Navarro H, Agúndez JAG, Jiménez-Jiménez FJ, Pastor P, Rajput A, Rajput A, Deuschl G, Kuhlenbäumer G, Girard SL, Farhan SMK, Dion PA, Rouleau GA.   +22 more
europepmc   +1 more source

Emergence, Challenges, and Opportunities for Chiral Nanocellulose Assemblies in Tissue Engineering and Wound Healing

Small Structures, Volume 7, Issue 3, March 2026.
This review explores chiral nanomaterials for tissue engineering and wound healing, specifically focusing on the potential of nanocellulose. The inherent chirality of nanocelluloses and their assemblies enables the creation of biomimetic scaffolds with unique biological interactions. Chiral nematic self‐assembly of cellulose nanocrystals, in particular,
Mahboubeh Nabavinia, Hossein Khanjanzadeh, Asier R. Muguruza, Anna Roig, Erlantz Lizundia, Justin O. Zoppe   +5 more
wiley   +1 more source

Lung Ultrasound Elastography: New Tools to Personalize Mechanical Ventilation. [PDF]

Am J Respir Crit Care Med
Girard M, Garcia D, Carrier FM, Cloutier G.   +3 more
europepmc   +1 more source

Antibiotic Resistance and Pathogenicity of Vibrio Species in Aquaculture: Implications for Fish Health and Food Safety in LMICs

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Pathogenic Vibrio species isolated from aquaculture environments in low‐ and middle‐income countries exhibit elevated antimicrobial resistance and multiple virulence traits. These findings highlight significant risks to fish health and food safety, underscoring the need for strengthened antimicrobial stewardship, robust biosecurity measures and ...
Asiphe Hobe, Luyanda Msolo, Kingsley Ehi Ebomah, Ishmael Festus Jaja, James Wabwire Oguttu, Anthony Ifeanyi Okoh   +5 more
wiley   +1 more source

Processes Driving Drift‐Ice Evolution and Its Interaction With the Oceanic and Atmospheric Boundary Layers

Reviews of Geophysics, Volume 64, Issue 1, March 2026.
Abstract Sea ice is a crucial component of polar climate systems and is undergoing substantial changes in both hemispheres due to evolving climatic conditions. Arctic sea ice is transitioning from perennial to seasonal cover, and the Southern Ocean sea ice is exhibiting recent minima and enhanced seasonality.
Jari Haapala, Morven Muilwijk, Ioanna Merkouriadi, Pedro Duarte, Ilker Fer, Mats A. Granskog, Virginie Guemas, Tore Hattermann, Robinson Hordoir, Doroteaciro Iovino, Polona Itkin, Roberta Pirazzini, Felix Pithan, Igor Polyakov, Annette Rinke, Letizia Tedesco, Petteri Uotila, Martin Vancoppenolle, Marcello Vichi, Timo Vihma   +19 more
wiley   +1 more source

Severe Delayed Hypersensitivity Reaction at Guselkumab Injection Site. [PDF]

Contact Dermatitis
Allichon S, Litovsky J, Sanchez M, Girard C, Granier G, Durand L, Henrion M, Philibert C, Le Souder C, Raison-Peyron N.   +9 more
europepmc   +1 more source

Evaluation of Global Storm‐Resolving Models in DYAMOND‐Winter: Radiation, Precipitation, Water Vapor, and Convective Organization

Journal of Advances in Modeling Earth Systems, Volume 18, Issue 3, March 2026.
Abstract We present a comprehensive evaluation of 13 global storm‐resolving models participating in the DYnamics of the Atmospheric general circulation Modeled On Non‐hydrostatic Domains (DYAMOND) Winter intercomparison project, focusing on their ability to simulate key atmospheric fields, such as precipitation rate, outgoing longwave radiation, and ...
Joonghyun In, Marat Khairoutdinov
wiley   +1 more source