Results 271 to 280 of about 319,994 (331)
Advancing the bioassay ontology through integrated PK/PD and safety pharmacology representation. [PDF]
Glenny-Pescov J +7 more
europepmc +1 more source
A novel and comprehensive 3D‐resolved kinetic Monte Carlo model coupled with mean square displacement analysis is introduced. This computational approach allows to explore, for the first time, the concentration and the state of charge effects on ionic diffusion coefficient and viscosity in methyl viologen‐based electrolytes used in organic redox flow ...
Jia Yu +2 more
wiley +1 more source
openaire +1 more source
The DO-KB knowledgebase 2026 update: expanding programmatic and language access. [PDF]
Baron JA +32 more
europepmc +1 more source
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu +4 more
wiley +1 more source
Workflow for Fine-Tuning and Evaluating DNA Language Models for Specific Genomics Issues. [PDF]
Nakamae K, Bono H.
europepmc +1 more source
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf +6 more
wiley +1 more source
igv-reports: embedding interactive genomic visualizations in HTML reports to aid variant review. [PDF]
Robinson JT +2 more
europepmc +1 more source

