Results 191 to 200 of about 1,088,541 (265)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Advancements in the manufacturing routes for the synthesis of marketed PARP inhibitors. [PDF]

RSC Adv
Rani D, Plebanski M, Chatterjee T.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Identification, characterization, and fungicide response of fungal pathogens causing postharvest diseases of watermelon (Citrullus lanatus) in Northern Thailand. [PDF]

Sci Rep
Suwannarach N, Kumla J.
europepmc   +1 more source

A decade of dedication: Giving, giving, giving... and giving up teaching

, 2012
Mulholland, Judith, Wallace, John
openaire   +1 more source

Assessing three altruism facets by economic games and self-report: a multitrait-multimethod investigation. [PDF]

Sci Rep
Binder L, Schultze M, Chen FS, Windmann S.   +3 more
europepmc   +1 more source

Inunngorfik - connection to land, inuit culture and giving birth in Kalaallit Nunaat: pregnant women's and their families' perspectives on the centralization of delivery services. [PDF]

Int J Circumpolar Health
Olesen I, Ingemann C, Larsen CVL, Ottendahl CB, Rubin SE, Bjerregaard P, Jensen T.   +6 more
europepmc   +1 more source

Asymmetric synthesis of alkyl fluorides <i>via</i> biocatalytic reduction of α-fluoroenones and α-fluoroenoates.

Green Chem
Allan H, Wang Y, Winterson B, King A, Aliev AE, Szpara R, Laserna V, Coomber CE, Ward JM, Jeffries JWE, Hailes HC, Sheppard TD.   +11 more
europepmc   +1 more source