Results 101 to 110 of about 416,494 (310)

Geomorphology of the Kaikoura area [PDF]

, 1968
The major physiographic units in the Kaikoura area are the Peninsula Block, Beach Ridges and Raised Beaches, Hard Rock Areas and the Alluvial Fans. Erosion of the Seaward Kaikoura Mountains and the transfer of the debris to the sea by fan streams have ...
Chandra, Satish
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Climatic Conditions in the Central Part of the Kashmir Valley During the Pleistocene–Holocene Transition: Insights from Lithostratigraphy, Geochemical Analyses, and Radiocarbon Chronology of Palaeosol Sequences

Atmosphere
The Kashmir Valley, characterized by its rich loess–palaeosol sequences (LPSs), provides a unique geo-archive for reconstructing Late Quaternary climate dynamics.
Rayees Ahmad Shah, Shakil Ahmad Romshoo, Imran Khan, Pankaj Kumar   +3 more
doaj   +1 more source

Changes in the seawater salinity-oxygen isotope relation between last glacial and present: sediment core data and OGCM modelling [PDF]

, 1998
The presently available paleotemperature data implies large ice-free areas in the Greenland- Iceland-Norwegian Seas during the Last Glacial Maximum 21 600 yr BP.
Schäfer-Neth, Christian
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Assessing glacier changes and hydrological impacts in the upper Indus Basin under CMIP6 climate scenarios

iScience
Summary: Glaciers in the Himalaya are vital for sustaining streamflow in the Upper Indus Basin. This study quantifies future glacier mass and area changes in the Jhelum sub-basin using projections from 13 bias-corrected CMIP6 climate models under SSP245 ...
Tariq Abdullah, Jasia Bashir, Shakil Ahmad Romshoo   +2 more
doaj   +1 more source

Processes acting to produce glacial detritus [PDF]

, 1969
The traditional view of attrition and abrasion as the major agents producing glacial debris is considered in the light of recent work by engineering geologists and geomorphologists.
Falconer, Allan
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source