Results 121 to 130 of about 416,494 (310)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A seasonal estimate of the Kumkol Basin glacier mass balance by satellite laser altimeter data and ASTER GDEM

Journal of Hydrology: Regional Studies
Study region: The Kumkol Basin, an alpine catchment whose rivers depend heavily on glacier-derived meltwater, where rising temperatures threaten ice reserves essential for downstream ecosystems and water supply.
Lailei Gu, Yanjun Che, Mingjun Zhang, Lihua Chen, Jiakang Wu   +4 more
doaj   +1 more source

Terrestrial glacial eskers: Analogs for Martian sinuous ridges [PDF]

A glacial model was introduced last year for the Argyre region, a concept which is now extended, and which was recently integrated with a Global Hydrologic Model incorporating many other aspects of Martian geology. Despite wide agreement that the Martian
Kargel, Jeffrey S., Strom, Roger G.
core   +1 more source

First ground penetrating radar survey on Monte Perdido glacier (Pyrenees) [PDF]

, 2016
Producción CientíficaThe project “The Monte Perdido Glacier: Monitoring the glacial dynamic and the associated cryospheric processes as indicators of global change” (National Park´s 2013 Fund) aims to study the recent dynamic and degradation of this ice
Heras Barrueco, Andrés, López Moreno, Juan Ignacio, Rico, Ibai, Río, Luis Mariano del, Serrano Cañadas, Enrique, Tejado, Juan José   +5 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Boulder Bands on Lobate Debris Aprons: Does Spatial Clustering Reveal Accumulation History for Martian Glaciations? [PDF]

Glacial landforms such as lobate debris aprons (LDA) and Concentric Crater Fill (CCF) are the dominant debris-covered glacial landforms on Mars. These landforms represent a volumetrically significant component of the Amazonian water ice budget, however ...
Cipolli, W., Fassett, C. I., Ishraque, F, Levy, J. S., Parsons, R., Tebolt, M.   +5 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

“Post-Glacial.” [PDF]

Geological Magazine, 1880
openaire   +4 more sources