Results 61 to 70 of about 416,494 (310)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

History Repeats: Large Scale Synchronous Biological Turnover in Avifauna From the Plio-Pleistocene and Late Holocene of New Zealand

Frontiers in Ecology and Evolution, 2019
New Zealand's unique biodiversity is the product of at least 55 million years of geographic isolation, supplemented by persistent transoceanic migration. Palaeontological and genetic evidence suggest most New Zealand avifauna has colonized from Australia.
Nicolas J. Rawlence, R. Paul Scofield, Matt S. McGlone, Michael Knapp   +3 more
doaj   +1 more source

A late Pleistocene long pollen record from Lake Urmia, NW Iran [PDF]

, 2008
A palynological study based on two 100-m long cores from Lake Urmia in northwestern Iran provides a vegetation record spanning 200 ka, the longest pollen record for the continental interior of the Near East.
Akhani, H, Amini, A, Andrieu-Ponel, V, Beaulieu, JLD, Brewer, S, Djamali, M, Lahijani, H, Leroy, SAG, Ponel, P, Shah-hosseini, M, Stevens, L   +10 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Evidence for late Quaternary surface rupture along the Leech River fault near Victoria, British Columbia [PDF]

, 2016
New surficial and bedrock mapping and paleoseismic trenching of the Leech River fault provide the first evidence for Quaternary surface-rupturing earthquakes in southwestern British Columbia, Canada.
Regalla, Christine
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Advances in mapping ice-free surfaces within the Northern Antarctic peninsula region using polarimetric RADARSAT-2 data [PDF]

, 2018
Ice-free areas within the Northern Antarctic Peninsula region are of interest for studying changes occurring to surface covers, including those related to glacial coverage, raised beach deposits and periglacial processes and permafrost. The objective
Guillaso, Stephane, Koch, Magaly, Lopez-Martinez, Jeronimo, Mink, Sandra, Nieto, Ana, Schmid, Thomas   +5 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Damping of glacial-interglacial cycles from anthropogenic forcing

, 2014
Climate variability over the past million years shows a strong glacial-interglacial cycle of ~100,000 years as a combined result of Milankovitch orbital forcing and climatic resonance.
Haqq-Misra, Jacob
core   +1 more source

Linking glacial-interglacial states to multiple equilibria of climate [PDF]

, 2018
Glacial-Interglacial cycles are often described as an amplified global response of the climate to perturbations in solar radiation caused by oscillations of Earth's orbit. However, it remains unclear whether internal feedbacks are large enough to account
Ferreira, David, Ito, Takamitsu, Marshall, John, McGee, David   +3 more
core   +1 more source