Results 71 to 80 of about 416,494 (310)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effect of Seismicity and Tectonic‐Glacial Interactions on Submarine Megaslides

Geophysical Research Letters
Enhanced sedimentation at glacial margins can produce submarine megaslides (>10,000 km3). We report a single megaslide in the Surveyor Fan, Gulf of Alaska. Minimum extant size is ∼16,124 km2 in area and ∼9,080 km3 in volume.
Sean P. S. Gulick, Robert S. Reece, Derek E. Sawyer, Gail L. Christeson, Brian K. Horton   +4 more
doaj   +1 more source

Recent glacial recession in the Rwenzori Mountains of East Africa due to rising air temperature [PDF]

, 2006
Based on field surveys and analyses of optical spaceborne images (LandSat5, LandSat7), we report recent decline in the areal extent of glaciers in the Rwenzori Mountains of East Africa from 2.01 +/- 0.56 km(2) in 1987 to 0.96 +/- 0.34 km(2) in 2003.
Majugu, A, Mileham, L, Muwanga, A, Nakileza, B, Taylor, RG, Tindimugaya, C   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Derivation of Del180 from sediment core log data\u27 Implications for millennial-scale climate change in the Labrador Sea [PDF]

, 2001
Sediment core logs from six sediment cores in the Labrador Sea show millennial-scale climate variability during the last glacial by recording all Heinrich events and several major Dansgaard-Oeschger cycles.
A. E. Aksu, Andrews, Best, Bond, Bond, Broecker, C. Hillaire-Marcel, Dansgaard, Dowdeswell, F. Rack, Francois, G. Bilodeau, Grootes, Hagelberg, Hamilton, Hamilton, Harris, Heinrich, Hillaire-Marcel, Hillaire-Marcel, Hiscott, Holler, Kissel, L. A. Mayer, Lazier, M. E. Weber, Mayer, Mayer, Mayer, McAyeal, McCave, Mienert, Moros, Oppo, Paillard, Pisias, R. N. Hiscott, Rasmussen, Schön, Shackleton, Stoner, Stoner, Sy, Weber, Weber, Wood   +45 more
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Deglacial Carbon Escape From the Northern Rim of the Southern Ocean

Geophysical Research Letters
The Southern Ocean regulates atmospheric CO2 and Earth's climate as a critical region for air‐sea gas exchange, delicately poised between being a CO2 source and sink.
N. E. Umling, E. Sikes, P. Rafter, N. F. Goodkin, J. R. Southon   +4 more
doaj   +1 more source

Effects of Pleistocene climate changes on species ranges and evolutionary processes in the Neotropical Atlantic Forest [PDF]

, 2016
The effects of global glaciations on the distribution of organisms is an essential element of many diversification models. However, the empirical evidence supporting this idea is mixed, in particular with respect to explaining tropical forest evolution ...
Cabanne, Gustavo Sebastián, Calderón, Pablo Luciano Sebastian, d'Horta, Fernando M., Flores, Pamela, Miyaki, Cristina Y., Pessoa, Rodrigo, Trujillo Arias, Natalia   +6 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source