Results 81 to 90 of about 416,494 (310)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Sedimentary Metagenomics Reveal Avian Community Transitions From the Last Glacial Maximum to the Holocene

Ecology and Evolution
The transition from the Last Glacial to the Holocene was marked by significant warming. This forced a compositional turnover of terrestrial plant and mammal communities discovered by diverse palaeoecological techniques. In this study, we analysed ancient
M. M. Sander, K. R. Stoof‐Leichsenring, S. Liu, W. Shen, S. Lisovski, U. Herzschuh   +5 more
doaj   +1 more source

Submarginal drumlin formation and late Holocene history of Fláajökull, southeast Iceland

Annals of Glaciology, 2016
Fláajökull is a non-surging outlet glacier draining the south-eastern part of the Vatnajökull, southeast Iceland. Fláajökull was stationary or advanced slightly between 1966 and 1995 and formed a prominent end moraine.
Sverrir Aðalsteinn Jónsson, Ívar Örn Benediktsson, Ólafur Ingólfsson, Anders Schomacker, Helga Lucia Bergsdóttir, William R. Jacobson, Hans Linderson   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Palaeoenvironment of a mesolithic peat bed from Austin Friars, Leicester [PDF]

, 1984
A mesolithic peat bed, dated to 9920±100 bp (HAR-4260) (bp = radiocarbon years before the present calculated from A.D. 19S0 within + or - of 100 years in this case. Ed.) was recovered from Austin Friars, Leicester.
Hunt, SA, Shackley, M
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Protracted post-glacial hydrocarbon seepage in the Barents Sea revealed by U–Th dating of seep carbonates

Frontiers in Earth Science
The hydrocarbon seepage chronology during deglaciation across the formerly glaciated Barents Sea was established using uranium-thorium (U–Th) dating of seep carbonates.
Tobias Himmler, Tobias Himmler, Tobias Himmler, Doris Wagner, Diana Sahy, Sunil Vadakkepuliyambatta, Sunil Vadakkepuliyambatta, Shyam Chand, Shyam Chand, Tõnu Martma, Kalle Kirsimäe, Rune Mattingsdal, Giuliana Panieri, Stefan Bünz, Daniel J. Condon, Jochen Knies, Jochen Knies, Aivo Lepland, Aivo Lepland, Aivo Lepland   +19 more
doaj   +1 more source

Glacial erosion: status and outlook

Annals of Glaciology, 2019
Glacier-erosion rates range across orders of magnitude, and much of this variation cannot be attributed to basal sliding rates. Subglacial till acts as lubricating ‘fault gouge’ or ‘sawdust’, and must be removed for rapid subglacial bedrock erosion. Such
R. B. Alley, K. M. Cuffey, L. K. Zoet
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source