Results 51 to 60 of about 111,275 (352)

Exploring Contrastive Representation for Weakly-Supervised Glacial Lake Extraction

Remote Sensing, 2023
Against the background of the ongoing atmospheric warming, the glacial lakes that are nourished and expanded in High Mountain Asia pose growing risks of glacial lake outburst floods (GLOFs) hazards and increasing threats to the downstream areas ...
Hang Zhao, Shuang Wang, Xuebin Liu, Fang Chen   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Systematic Extraction Approach for Mapping Glacial Lakes in High Mountain Regions of Asia

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2018
Glacial lakes are highly sensitive indicators of global climate change. The accurate extraction of glacial lakes from image data is of great importance to the evaluation of the hydrological environment in high mountain regions.
Hang Zhao, Fang Chen, Meimei Zhang
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Forewarning Model for Glacial Lake Outburst in Southeast Tibet

Applied Sciences, 2023
The southeast region of Tibet experiences frequent glacial lake outburst disasters, and disaster warning systems are thus crucial for disaster prevention and mitigation in the area.
Jiajia Gao, Jun Du, Zhuoma Yixi
doaj   +1 more source

Changes in Imja Tsho in the Mount Everest Region of Nepal [PDF]

, 2014
Imja Tsho, located in the Sagarmatha ( Everest) National Park of Nepal, is one of the most studied and rapidly growing lakes in the Himalayan range. Compared with previous studies, the results of our sonar bathymetric survey conducted in September of ...
Byers, A. C., McKinney, D. C., Rounce, D. R., Somos-Valenzuela, M. A.   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combined use of multi-source satellite imagery and deep learning for automated mapping of glacial lakes in the Bhutan Himalaya

Science of Remote Sensing
Himalayan glacial lakes have been rapidly developing and expanding in recent decades under climate change and glacier mass loss. These growing glacial lakes can produce glacial lake outburst floods (GLOFs) events with far-reaching and devastating ...
Xingyu Xu, Lin Liu, Lingcao Huang, Yan Hu   +3 more
doaj   +1 more source

Mapping Area Changes of Glacial Lakes Using Stacks of Optical Satellite Images

Remote Sensing, 2022
Glacial lakes are an important and dynamic component of terrestrial meltwater storage, responding to climate change and glacier retreat. Although there is evidence of rapid worldwide growth of glacial lakes, changes in frequency and magnitude of glacier ...
Varvara Bazilova, Andreas Kääb
doaj   +1 more source