Results 51 to 60 of about 73,324 (308)
Evidence of late Quaternary environmental change in a continental east Antarctic lake from lacustrine sedimentary pigment distributions [PDF]
, 2005 A sediment core from Progress Lake, one of the oldest lacustrine sequences in East Antarctica, contains distinct zones dating from a previous interglacial (most likely Marine Isotope Stage 5e, c.
Hodgson, D A, Keely, B J, Squier, A H
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Geomatics, Natural Hazards & Risk, 2023 Due to climate change, the future Glacial Lake Outburst Flood (GLOF) risk is more likely in the Himalayas. Despite several GLOF studies, little attention has been given to the combined surge that can result from a pair of upstream-downstream glacial ...
Manish Raj Gouli +3 more
doaj +1 more source
Calcite covering of sediment as a possible way of curbing blue-green algae [PDF]
, 1992 Natural calcite precipitation in lakes is a well-known control mechanism of eutrophication. In hard-water lakes, calcite deposits on the flat bottoms of shallow lakes and near the shores of deeper lakes resulted from biogenic decalcification during the ...
Klapper, H.
core
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Integrated Environmental Assessment and Management, EarlyView., 2023 Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves +6 more
wiley +1 more source
Glacial lake drainage: a stability analysis [PDF]
Annals of Glaciology, 1997 A model has been formulated to determine the stability regimes for water flow in a Subglacial conduit draining from a reservoir. The physics of the water flow is described with a set of differential equations expressing conservation of mass, momentum and energy.
Szilder, K. +2 more
openaire +2 more sources
Reconciling diverse lacustrine and terrestrial system response to penultimate deglacial warming in southern Europe [PDF]
, 2015 Unlike the most recent deglaciation, the regional expression of climate changes during the penultimate deglaciation remains understudied, even though it led into a period of excess warmth with estimates of global average temperature 1–2 °C, and sea level
Frogley, Michael R +4 more
core +3 more sources
Advanced Functional Materials, EarlyView.Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley +12 more
wiley +1 more source